Wei et al. find that Fap is an osteogenic suppressor that could be targeted to promote bone formation and inhibit bone resorption. Genetic and pharmacological inhibition of Fap attenuates aging- and ovariectomy-induced bone loss in mice, while Osteolectin functions as an endogenous inhibitor of Fap to promote mineralization in zebrafish.
- bone formation
- bone resorption
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)