@article{5d5d6befd8da469b9a1740526916dcbc,
title = "Identification of Fibroblast Activation Protein as an Osteogenic Suppressor and Anti-osteoporosis Drug Target",
abstract = "Wei et al. find that Fap is an osteogenic suppressor that could be targeted to promote bone formation and inhibit bone resorption. Genetic and pharmacological inhibition of Fap attenuates aging- and ovariectomy-induced bone loss in mice, while Osteolectin functions as an endogenous inhibitor of Fap to promote mineralization in zebrafish.",
keywords = "Clec11a, Fap, bone formation, bone resorption, mineralization, osteogenesis, osteolectin, osteoporosis, zebrafish",
author = "Hanjing Wei and Yanhua Xu and Yibin Wang and Liting Xu and Chunyang Mo and Liangzi Li and Bo Shen and Yao Sun and Pengzhen Cheng and Liu Yang and Yichuan Pang and An Qin and Ying Cao and Morrison, {Sean J.} and Rui Yue",
note = "Funding Information: This work was supported by grants from the National Key Program on Stem Cell and Translational Research ( 2017YFA0106400 ), the National Natural Science Foundation of China ( 91749124 and 81772389 ), and the Fundamental Research Funds for the Central Universities ( 22120190149 and kx0200020173386 ). Publisher Copyright: {\textcopyright} 2020 The Authors",
year = "2020",
month = oct,
day = "13",
doi = "10.1016/j.celrep.2020.108252",
language = "English (US)",
volume = "33",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "2",
}