Abstract
We have identified and partially purified from bovine brain a factor which stimulates the activities of two rat liver calcium-dependent proteases. The factor, which is physically and functionally distinct from calmodulin, is heat stable and has a low apparent molecular weight (Mr 20000). The factor stimulates rates of proteolysis up to 25-fold but does not alter the calcium sensitivity of either protease. We have called this factor calcium-dependent protease regulator.
Original language | English (US) |
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Pages (from-to) | 4297-4303 |
Number of pages | 7 |
Journal | Biochemistry |
Volume | 21 |
Issue number | 18 |
DOIs | |
State | Published - Aug 1982 |
ASJC Scopus subject areas
- Biochemistry