Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265

Medicine & Life Sciences

• DSM265 100%
• dihydroorotate dehydrogenase 78%
• Plasmodium falciparum 48%
• Point Mutation 45%
• In Vitro Techniques 20%
• Parasites 17%
• Malaria 14%
• Mutation 11%
• Atovaquone 8%
• 4,6-dinitro-o-cresol 7%
• Gene Editing 6%
• Plasmodium 6%
• Clustered Regularly Interspaced Short Palindromic Repeats 5%
• Communicable Diseases 4%
• X-Rays 3%
• Binding Sites 3%
• Amino Acids 3%
• Clinical Studies 3%
• Enzymes 2%
• Therapeutics 2%