Iatrogenic myocardial edema with potassium cardioplegia

R. P. Foglia, D. L. Steed, D. M. Follette, E. DeLand, G. D. Buckberg

Research output: Contribution to journalArticlepeer-review

88 Scopus citations


Postischemic myocardial edema depresses left ventricular function and coronary perfusion. Pharmacologic cardioplegia is being used increasingly to enhance myocardial protection during cardiac operations. In the present study we varied the colloid osmotic and osmotic pressures and the infusion pressures of four cardioplegic solutions to determine their respective roles in producing or preventing myocardial edema in a nonischemic setting. We found that myocardial edema during potassium cardioplegia is independent of infusion pressures, is caused by isosmotic crystalloid solutions, is worsened by hyposmolar crystalloid solutions, is avoided by the addition of colloid, and is avoided if the solution is made hyperosmotic with the addition of mannitol.

Original languageEnglish (US)
Pages (from-to)217-222
Number of pages6
JournalJournal of Thoracic and Cardiovascular Surgery
Issue number2
StatePublished - 1979

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


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