Abstract
Ia-bearing macrophages from spleens and peritoneal cavities of athymic (nu/nu) and euthymic (nu/+) were compared. Macrophages from both strains of mice had equal antigen-presenting ability. The basal numbers of unstimulated Ia-bearing peritoneal macrophages were equal, but only euthymic mice recruited large numbers of Ia-bearing macrophages after Listeria infection. The i.p. injections of a 'macrophage Ia-recruiting factor' induced exudates rich in Ia-bearing macrophages in both athymic and euthymic mice. These data suggest 2 levels of control of Ia-bearing macrophages: a basal T cell-independent level and a stimulated level dependent on mature T cell.
Original language | English (US) |
---|---|
Pages (from-to) | 2496-2498 |
Number of pages | 3 |
Journal | Journal of Immunology |
Volume | 126 |
Issue number | 6 |
State | Published - 1981 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology