Hypovolemic shock promotes neutrophil sequestration in lungs by a xanthine oxidase-related mechanism

B. O. Anderson; E. E. Moore; F. A. Moore; J. A. Leff; L. S. Terada; A. H. Harken; J. E. Repine

doi:10.1152/jappl.1991.71.5.1862

Hypovolemic shock promotes neutrophil sequestration in lungs by a xanthine oxidase-related mechanism

B. O. Anderson, E. E. Moore, F. A. Moore, J. A. Leff, L. S. Terada, A. H. Harken, J. E. Repine

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59 Scopus citations

Abstract

Our results suggest that xanthine oxidase (XO) contributes to lung neutrophil sequestration in hypovolemic shock. Catheterized rats subjected to shock by phlebotomy (~30% blood loss) had decreased mean arterial blood pressures (P < 0.05) and increased (P < 0.05) lung myeloperoxidase (MPO) activities (indicative of lung neutrophil accumulation) compared with sham- treated normotensive rats. In contrast, rats depleted of lung and plasma XO activity by tungsten diet before phlebotomy had decreased (P < 0.05) lung MPO activities compared with phlebotomized rats fed regular diets.

Original language	English (US)
Pages (from-to)	1862-1865
Number of pages	4
Journal	Journal of applied physiology
Volume	71
Issue number	5
DOIs	https://doi.org/10.1152/jappl.1991.71.5.1862
State	Published - 1991

Keywords

adult respiratory distress syndrome
ischemia- reperfusion
myeloperoxidase
oxygen radicals
vascular injury

ASJC Scopus subject areas

Physiology
Physiology (medical)

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10.1152/jappl.1991.71.5.1862

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title = "Hypovolemic shock promotes neutrophil sequestration in lungs by a xanthine oxidase-related mechanism",

abstract = "Our results suggest that xanthine oxidase (XO) contributes to lung neutrophil sequestration in hypovolemic shock. Catheterized rats subjected to shock by phlebotomy (~30% blood loss) had decreased mean arterial blood pressures (P < 0.05) and increased (P < 0.05) lung myeloperoxidase (MPO) activities (indicative of lung neutrophil accumulation) compared with sham- treated normotensive rats. In contrast, rats depleted of lung and plasma XO activity by tungsten diet before phlebotomy had decreased (P < 0.05) lung MPO activities compared with phlebotomized rats fed regular diets.",

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AU - Anderson, B. O.

AU - Moore, E. E.

AU - Moore, F. A.

AU - Leff, J. A.

AU - Terada, L. S.

AU - Harken, A. H.

AU - Repine, J. E.

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AB - Our results suggest that xanthine oxidase (XO) contributes to lung neutrophil sequestration in hypovolemic shock. Catheterized rats subjected to shock by phlebotomy (~30% blood loss) had decreased mean arterial blood pressures (P < 0.05) and increased (P < 0.05) lung myeloperoxidase (MPO) activities (indicative of lung neutrophil accumulation) compared with sham- treated normotensive rats. In contrast, rats depleted of lung and plasma XO activity by tungsten diet before phlebotomy had decreased (P < 0.05) lung MPO activities compared with phlebotomized rats fed regular diets.

KW - adult respiratory distress syndrome

KW - ischemia- reperfusion

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KW - oxygen radicals

KW - vascular injury

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Hypovolemic shock promotes neutrophil sequestration in lungs by a xanthine oxidase-related mechanism

Abstract

Keywords

ASJC Scopus subject areas

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