Hypothalamic pathology in Alzheimer's disease

Clifford B. Saper; Dwight C. German

doi:10.1016/0304-3940(87)90325-9

Hypothalamic pathology in Alzheimer's disease

Clifford B. Saper, Dwight C. German

Research output: Contribution to journal › Article › peer-review

139 Scopus citations

Abstract

The hypothalamus was examined in 3 cases of Alzheimer's disease and 3 control brains, using combined acetylcholinesterase (AChE) and thioflavin-S staining. Neurons undergoing neurofibrillary degeneration were restricted to 3 AChE-positive cell populations (lateral tuberal, lateral posterior and tuberomammillary) that have been found in the rat and monkey to project to the cerebral cortex. Our results suggest that the neurofibrillary degeneration in the hypothalamus involves primarily neurons that innervate cortical areas involved by Alzheimer's disease. This finding is consistent with the hypothesis that Alzheimer's disease is transmitted from neuron to neuron via normal neuronal connections.

Original language	English (US)
Pages (from-to)	364-370
Number of pages	7
Journal	Neuroscience letters
Volume	74
Issue number	3
DOIs	https://doi.org/10.1016/0304-3940(87)90325-9
State	Published - Mar 9 1987

Keywords

Acetylcholinesterase
Lateral hypothalamic area
Man
Neurofibrillary tangle
Tuberomammillary nucleus

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(87)90325-9

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title = "Hypothalamic pathology in Alzheimer's disease",

abstract = "The hypothalamus was examined in 3 cases of Alzheimer's disease and 3 control brains, using combined acetylcholinesterase (AChE) and thioflavin-S staining. Neurons undergoing neurofibrillary degeneration were restricted to 3 AChE-positive cell populations (lateral tuberal, lateral posterior and tuberomammillary) that have been found in the rat and monkey to project to the cerebral cortex. Our results suggest that the neurofibrillary degeneration in the hypothalamus involves primarily neurons that innervate cortical areas involved by Alzheimer's disease. This finding is consistent with the hypothesis that Alzheimer's disease is transmitted from neuron to neuron via normal neuronal connections.",

keywords = "Acetylcholinesterase, Lateral hypothalamic area, Man, Neurofibrillary tangle, Tuberomammillary nucleus",

author = "Saper, {Clifford B.} and German, {Dwight C.}",

note = "Funding Information: The authors thank Quan Hue Ha for excellent technical assistance. Supported by Grants NS22835 and NS20030, from NINCDS, the American Heart Association 850894, the Otho Sprague Fund, the Brain Research Foundation, the Aradine S. Ard Fund, the Greater Dallas ADRDA, and the Lou and Ellen McGinley Lectureship. C.B.S. was the recipient ofa McKnight Scholar Award. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1987",

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doi = "10.1016/0304-3940(87)90325-9",

language = "English (US)",

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AU - German, Dwight C.

N1 - Funding Information: The authors thank Quan Hue Ha for excellent technical assistance. Supported by Grants NS22835 and NS20030, from NINCDS, the American Heart Association 850894, the Otho Sprague Fund, the Brain Research Foundation, the Aradine S. Ard Fund, the Greater Dallas ADRDA, and the Lou and Ellen McGinley Lectureship. C.B.S. was the recipient ofa McKnight Scholar Award. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1987/3/9

Y1 - 1987/3/9

N2 - The hypothalamus was examined in 3 cases of Alzheimer's disease and 3 control brains, using combined acetylcholinesterase (AChE) and thioflavin-S staining. Neurons undergoing neurofibrillary degeneration were restricted to 3 AChE-positive cell populations (lateral tuberal, lateral posterior and tuberomammillary) that have been found in the rat and monkey to project to the cerebral cortex. Our results suggest that the neurofibrillary degeneration in the hypothalamus involves primarily neurons that innervate cortical areas involved by Alzheimer's disease. This finding is consistent with the hypothesis that Alzheimer's disease is transmitted from neuron to neuron via normal neuronal connections.

AB - The hypothalamus was examined in 3 cases of Alzheimer's disease and 3 control brains, using combined acetylcholinesterase (AChE) and thioflavin-S staining. Neurons undergoing neurofibrillary degeneration were restricted to 3 AChE-positive cell populations (lateral tuberal, lateral posterior and tuberomammillary) that have been found in the rat and monkey to project to the cerebral cortex. Our results suggest that the neurofibrillary degeneration in the hypothalamus involves primarily neurons that innervate cortical areas involved by Alzheimer's disease. This finding is consistent with the hypothesis that Alzheimer's disease is transmitted from neuron to neuron via normal neuronal connections.

KW - Acetylcholinesterase

KW - Lateral hypothalamic area

KW - Man

KW - Neurofibrillary tangle

KW - Tuberomammillary nucleus

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JO - Neuroscience letters

JF - Neuroscience letters

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ER -

Hypothalamic pathology in Alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

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