Hypertrophy and hyperplasia of somatostatin containing D cells in diabetes

L. Orci, D. Baetens, C. Rufener, M. Amherdt, M. Ravazzola, P. Studer, F. Malaisse-Lagae, Roger H Unger

Research output: Contribution to journalArticlepeer-review

211 Scopus citations


Insulin, glucagon, and somatostatin containing cells, identified by immunofluorescent staining, were quantitated morphometrically in sections of pancreas obtained from diabetic and nondiabetic humans and rats. Both the volume density and number of somatostatin and glucagon containing cells were significantly increased in the islets of juvenile type human diabetics and of streptozotocin in diabetic rats.

Original languageEnglish (US)
Pages (from-to)1338-1342
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number4
StatePublished - 1976

ASJC Scopus subject areas

  • General


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