Hyperpolarized 89Y offers the potential of direct imaging of metal ions in biological systems by magnetic resonance

Matthew E. Merritt; Crystal Harrison; Zoltan Kovacs; Preeti Kshirsagar; Craig R. Malloy; A. Dean Sherry

doi:10.1021/ja075768z

Hyperpolarized ⁸⁹Y offers the potential of direct imaging of metal ions in biological systems by magnetic resonance

Matthew E. Merritt, Crystal Harrison, Zoltan Kovacs, Preeti Kshirsagar, Craig R. Malloy, A. Dean Sherry

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Hyperpolarization of ⁸⁹YCl₃ and three ⁸⁹Y-complexes was achieved by dynamic nuclear polarization of aqueous samples. The long T₁s of ⁸⁹Y make its application as an NMR imaging probe extremely promising. In addition, the wide chemical shift range for various chelates of ⁸⁹Y means that agents sensitive to their biological/chemical milieu could serve as exquisite sensors of important biological events.

Original language	English (US)
Pages (from-to)	12942-12943
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	129
Issue number	43
DOIs	https://doi.org/10.1021/ja075768z
State	Published - Oct 31 2007

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja075768z

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title = "Hyperpolarized 89Y offers the potential of direct imaging of metal ions in biological systems by magnetic resonance",

abstract = "Hyperpolarization of 89YCl3 and three 89Y-complexes was achieved by dynamic nuclear polarization of aqueous samples. The long T1s of 89Y make its application as an NMR imaging probe extremely promising. In addition, the wide chemical shift range for various chelates of 89Y means that agents sensitive to their biological/chemical milieu could serve as exquisite sensors of important biological events.",

author = "Merritt, {Matthew E.} and Crystal Harrison and Zoltan Kovacs and Preeti Kshirsagar and Malloy, {Craig R.} and Sherry, {A. Dean}",

year = "2007",

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AU - Merritt, Matthew E.

AU - Harrison, Crystal

AU - Kovacs, Zoltan

AU - Kshirsagar, Preeti

AU - Malloy, Craig R.

AU - Sherry, A. Dean

PY - 2007/10/31

Y1 - 2007/10/31

N2 - Hyperpolarization of 89YCl3 and three 89Y-complexes was achieved by dynamic nuclear polarization of aqueous samples. The long T1s of 89Y make its application as an NMR imaging probe extremely promising. In addition, the wide chemical shift range for various chelates of 89Y means that agents sensitive to their biological/chemical milieu could serve as exquisite sensors of important biological events.

AB - Hyperpolarization of 89YCl3 and three 89Y-complexes was achieved by dynamic nuclear polarization of aqueous samples. The long T1s of 89Y make its application as an NMR imaging probe extremely promising. In addition, the wide chemical shift range for various chelates of 89Y means that agents sensitive to their biological/chemical milieu could serve as exquisite sensors of important biological events.

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Hyperpolarized ⁸⁹Y offers the potential of direct imaging of metal ions in biological systems by magnetic resonance

Abstract

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