Hybrid imaging with 99mTc-WBC SPECT/CT to monitor the effect of therapy in diabetic foot osteomyelitis

Francisco Lazaga; Suzanne Av Van Asten; Adam Nichols; Kavita Bhavan; Javier La Fontaine; Orhan K. Oz; Lawrence A. Lavery

doi:10.1111/iwj.12433

Hybrid imaging with 99mTc-WBC SPECT/CT to monitor the effect of therapy in diabetic foot osteomyelitis

Francisco Lazaga, Suzanne Av Van Asten, Adam Nichols, Kavita Bhavan, Javier La Fontaine, Orhan K. Oz, Lawrence A. Lavery

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

This study sought to assess the utility of monitoring response to treatment of diabetic foot osteomyelitis (DFO) with Tc-99m WBC-labelled single photon emission computed tomography (SPECT/CT) imaging. This is a retrospective cohort study of 20 patients with DFO with sequential Tc-99m WBC-labelled SPECT/CT imaging. Radiologic findings of osteomyelitis were evaluated and imaging results were correlated with clinical outcomes subtracted from chart review. Successful treatment of osteomyelitis was defined by wound healing and/or lack of re-admission for bone infection of the same site within 1 year. The sensitivity, specificity, positive predictive value and negative predictive value of SPECT/CT to determine osteomyelitis treatment remission were 90%, 56%, 69% and 83%, respectively. Tc-99m WBC-labelled SPECT/CT imaging may be useful to help determine treatment outcomes for DFO.

Original language	English (US)
Pages (from-to)	1158-1160
Number of pages	3
Journal	International Wound Journal
Volume	13
Issue number	6
DOIs	https://doi.org/10.1111/iwj.12433
State	Published - Dec 2016

Keywords

Diabetic foot
Imaging
Infection
Osteomyelitis
SPECT/CT

ASJC Scopus subject areas

Surgery
Dermatology

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10.1111/iwj.12433

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title = "Hybrid imaging with 99mTc-WBC SPECT/CT to monitor the effect of therapy in diabetic foot osteomyelitis",

abstract = "This study sought to assess the utility of monitoring response to treatment of diabetic foot osteomyelitis (DFO) with Tc-99m WBC-labelled single photon emission computed tomography (SPECT/CT) imaging. This is a retrospective cohort study of 20 patients with DFO with sequential Tc-99m WBC-labelled SPECT/CT imaging. Radiologic findings of osteomyelitis were evaluated and imaging results were correlated with clinical outcomes subtracted from chart review. Successful treatment of osteomyelitis was defined by wound healing and/or lack of re-admission for bone infection of the same site within 1 year. The sensitivity, specificity, positive predictive value and negative predictive value of SPECT/CT to determine osteomyelitis treatment remission were 90%, 56%, 69% and 83%, respectively. Tc-99m WBC-labelled SPECT/CT imaging may be useful to help determine treatment outcomes for DFO.",

keywords = "Diabetic foot, Imaging, Infection, Osteomyelitis, SPECT/CT",

author = "Francisco Lazaga and {Van Asten}, {Suzanne Av} and Adam Nichols and Kavita Bhavan and {La Fontaine}, Javier and Oz, {Orhan K.} and Lavery, {Lawrence A.}",

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year = "2016",

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doi = "10.1111/iwj.12433",

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AU - Lazaga, Francisco

AU - Van Asten, Suzanne Av

AU - Nichols, Adam

AU - Bhavan, Kavita

AU - La Fontaine, Javier

AU - Oz, Orhan K.

AU - Lavery, Lawrence A.

PY - 2016/12

Y1 - 2016/12

N2 - This study sought to assess the utility of monitoring response to treatment of diabetic foot osteomyelitis (DFO) with Tc-99m WBC-labelled single photon emission computed tomography (SPECT/CT) imaging. This is a retrospective cohort study of 20 patients with DFO with sequential Tc-99m WBC-labelled SPECT/CT imaging. Radiologic findings of osteomyelitis were evaluated and imaging results were correlated with clinical outcomes subtracted from chart review. Successful treatment of osteomyelitis was defined by wound healing and/or lack of re-admission for bone infection of the same site within 1 year. The sensitivity, specificity, positive predictive value and negative predictive value of SPECT/CT to determine osteomyelitis treatment remission were 90%, 56%, 69% and 83%, respectively. Tc-99m WBC-labelled SPECT/CT imaging may be useful to help determine treatment outcomes for DFO.

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KW - Diabetic foot

KW - Imaging

KW - Infection

KW - Osteomyelitis

KW - SPECT/CT

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Hybrid imaging with 99mTc-WBC SPECT/CT to monitor the effect of therapy in diabetic foot osteomyelitis

Abstract

Keywords

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