Hyaluronan biology: A complex balancing act of structure, function, location and context

Stavros Garantziotis, Rashmin C. Savani

Research output: Contribution to journalReview articlepeer-review

167 Scopus citations


Cell-matrix interactions are fundamental to many developmental, homeostatic, immune and pathologic processes. Hyaluronan (HA), a critical component of the extracellular matrix (ECM) that regulates normal structural integrity and development, also regulates tissue responses during injury, repair, and regeneration. Though simple in its primary structure, HA regulates biological responses in a highly complex manner with balanced contributions from its molecular size and concentration, synthesis versus enzymatic and/or oxidative-nitrative fragmentation, interactions with key HA binding proteins and cell associated receptors, and its cell context-specific signaling. This review highlights the different, but inter-related factors that dictate the biological activity of HA and introduces the overarching themes that weave throughout this special issue of Matrix Biology on hyaluronan.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalMatrix Biology
StatePublished - May 2019
Externally publishedYes


  • Degradation
  • Hyaluronan
  • Receptors
  • Signaling
  • Structure
  • Synthesis

ASJC Scopus subject areas

  • Molecular Biology


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