Huntington’s disease: Cellular and molecular basis of pathology

V. V. Korzhova; D. N. Artamonov; O. L. Vlasova; I. B. Bezprozvanny

doi:10.7868/S004446771404008X

Huntington’s disease: Cellular and molecular basis of pathology

V. V. Korzhova, D. N. Artamonov, O. L. Vlasova, I. B. Bezprozvanny

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Huntington’s disease (HD) is an inherited autosomal dominant neurodegenerative disorder caused by a polyQ expansion (>36 glutamine repeats) in Huntingtin (Htt) protein. It is believed that dysfunction of corticostriatal system is one of the main pathological events. Special attention is paid to synaptic dysfunction of transmission between cortical and striatal neurons. This review focuses on modern concepts of molecular and cellular mechanisms of HD pathology and especially on alterations in corticostriatal connectivity. Calcium hypothesis of HD and new pharmacological targets are described.

Original language	English (US)
Pages (from-to)	359-375
Number of pages	17
Journal	Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova
Volume	64
Issue number	4
DOIs	https://doi.org/10.7868/S004446771404008X
State	Published - 2014

Keywords

Dendritic spines
Huntington’s disease
Striatum
Synaptic transmission

ASJC Scopus subject areas

Neuroscience(all)

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10.7868/S004446771404008X

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AB - Huntington’s disease (HD) is an inherited autosomal dominant neurodegenerative disorder caused by a polyQ expansion (>36 glutamine repeats) in Huntingtin (Htt) protein. It is believed that dysfunction of corticostriatal system is one of the main pathological events. Special attention is paid to synaptic dysfunction of transmission between cortical and striatal neurons. This review focuses on modern concepts of molecular and cellular mechanisms of HD pathology and especially on alterations in corticostriatal connectivity. Calcium hypothesis of HD and new pharmacological targets are described.

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Huntington’s disease: Cellular and molecular basis of pathology

Abstract

Keywords

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