Human lymphocytes recognise mouse alloantigens

Kirsten Fischer Lindahl; Fritz H. Bach

doi:10.1038/254607a0

Human lymphocytes recognise mouse alloantigens

Kirsten Fischer Lindahl, Fritz H. Bach

Immunology

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Abstract

H-2 LD antigens¹ of the mouse major histocompatibility complex and the lymphocyte-activating determinants of the Mls (ref. 2) locus induce vigorous lymphocyte proliferation and enhance generation of cytotoxic effector cells in allogeneic combinations (ref. 3 and D. J. Schendel, and F. H. Bach, unpublished). These antigens do not serve well as targets for cell-mediated lympholysis (CML) - a function which in the mouse is performed by the classical H-2 determinants, the SD antigens^4,5. A similar differential function of LD and SD antigens is found in human allograft reactions in vitro ⁶.

Original language	English (US)
Pages (from-to)	607-609
Number of pages	3
Journal	Nature
Volume	254
Issue number	5501
DOIs	https://doi.org/10.1038/254607a0
State	Published - 1975

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title = "Human lymphocytes recognise mouse alloantigens",

abstract = "H-2 LD antigens1 of the mouse major histocompatibility complex and the lymphocyte-activating determinants of the Mls (ref. 2) locus induce vigorous lymphocyte proliferation and enhance generation of cytotoxic effector cells in allogeneic combinations (ref. 3 and D. J. Schendel, and F. H. Bach, unpublished). These antigens do not serve well as targets for cell-mediated lympholysis (CML) - a function which in the mouse is performed by the classical H-2 determinants, the SD antigens4,5. A similar differential function of LD and SD antigens is found in human allograft reactions in vitro 6.",

author = "Lindahl, {Kirsten Fischer} and Bach, {Fritz H.}",

year = "1975",

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AU - Lindahl, Kirsten Fischer

AU - Bach, Fritz H.

PY - 1975

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N2 - H-2 LD antigens1 of the mouse major histocompatibility complex and the lymphocyte-activating determinants of the Mls (ref. 2) locus induce vigorous lymphocyte proliferation and enhance generation of cytotoxic effector cells in allogeneic combinations (ref. 3 and D. J. Schendel, and F. H. Bach, unpublished). These antigens do not serve well as targets for cell-mediated lympholysis (CML) - a function which in the mouse is performed by the classical H-2 determinants, the SD antigens4,5. A similar differential function of LD and SD antigens is found in human allograft reactions in vitro 6.

AB - H-2 LD antigens1 of the mouse major histocompatibility complex and the lymphocyte-activating determinants of the Mls (ref. 2) locus induce vigorous lymphocyte proliferation and enhance generation of cytotoxic effector cells in allogeneic combinations (ref. 3 and D. J. Schendel, and F. H. Bach, unpublished). These antigens do not serve well as targets for cell-mediated lympholysis (CML) - a function which in the mouse is performed by the classical H-2 determinants, the SD antigens4,5. A similar differential function of LD and SD antigens is found in human allograft reactions in vitro 6.

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Human lymphocytes recognise mouse alloantigens

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