Human Immunodeficiency Virus Type 1 Tat Regulates Endothelial Cell Actin Cytoskeletal Dynamics through PAK1 Activation and Oxidant Production

Medicine & Life Sciences

• p21-Activated Kinases 100%
• Glutathione Transferase 73%
• Oxidants 72%
• HIV-1 60%
• Actins 58%
• Endothelial Cells 51%
• NADPH Oxidases 34%
• fluorescent protein 583 31%
• Human Umbilical Vein Endothelial Cells 21%
• Actin Cytoskeleton 19%
• 4-ethoxymethylene-2-phenyl-2-oxazoline-5-one 14%
• tat Gene Products 14%
• Phosphorylation 13%
• Stress Fibers 12%
• JNK Mitogen-Activated Protein Kinases 11%
• Superoxides 9%
• Cytoskeleton 9%
• Adenoviridae 9%
• Cysteine 9%
• Acquired Immunodeficiency Syndrome 8%
• Phosphotransferases 7%
• Membranes 5%
• Mutation 5%
• Lung 5%

Agriculture & Biology

• Human immunodeficiency virus 1 85%
• endothelial cells 71%
• oxidants 67%
• actin 65%
• phosphotransferases (kinases) 59%
• glutathione transferase 58%
• NAD(P)H oxidase (H2O2-forming) 31%
• human umbilical vein endothelial cells 25%
• microfilaments 18%
• phosphorylation 15%
• angiogenesis 10%
• Adenoviridae 9%
• mitogen-activated protein kinase 9%
• cytoskeleton 9%
• crossover interference 8%
• superoxide anion 8%
• cysteine 7%
• lungs 6%
• mutation 5%
• mutants 5%
• proteins 2%
• cells 2%