TY - JOUR
T1 - Human bocavirus
T2 - Clinical significance and implications
AU - Kahn, Jeffrey
N1 - Funding Information:
The fund from the Hong Kong Polytechnic University to support this project Is gratefully acknowledged.
PY - 2008/2
Y1 - 2008/2
N2 - PURPOSE OF REVIEW: Human bocavirus (HBoV), a parvovirus, was discovered in 2005 with the use of nonspecific genome amplification techniques. Since its discovery, HBoV has been identified worldwide. This review will focus on the epidemiology and clinical features associated with HBoV infection. RECENT FINDINGS: Initial studies demonstrated the presence of HBoV DNA in respiratory specimens of individuals with respiratory tract disease. Data from some studies suggest that HBoV may be the etiological agent responsible for respiratory tract disease, particularly in young children. HBoV, however, is frequently detected in the presence of other common respiratory viruses. HBoV is not confined to the respiratory tract as evidence of the virus has been detected in serum and stool, the significance of which remains unclear. Presence of the virus in respiratory secretions, serum and stool suggests that this virus may cause systemic illness. SUMMARY: HBoV is an emerging human parvovirus. The full spectrum of disease associated with HBoV remains to be defined.
AB - PURPOSE OF REVIEW: Human bocavirus (HBoV), a parvovirus, was discovered in 2005 with the use of nonspecific genome amplification techniques. Since its discovery, HBoV has been identified worldwide. This review will focus on the epidemiology and clinical features associated with HBoV infection. RECENT FINDINGS: Initial studies demonstrated the presence of HBoV DNA in respiratory specimens of individuals with respiratory tract disease. Data from some studies suggest that HBoV may be the etiological agent responsible for respiratory tract disease, particularly in young children. HBoV, however, is frequently detected in the presence of other common respiratory viruses. HBoV is not confined to the respiratory tract as evidence of the virus has been detected in serum and stool, the significance of which remains unclear. Presence of the virus in respiratory secretions, serum and stool suggests that this virus may cause systemic illness. SUMMARY: HBoV is an emerging human parvovirus. The full spectrum of disease associated with HBoV remains to be defined.
KW - Gastrointestinal disease
KW - Human bocavirus
KW - Human parvovirus
KW - Respiratory tract disease
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U2 - 10.1097/MOP.0b013e3282f3f518
DO - 10.1097/MOP.0b013e3282f3f518
M3 - Review article
C2 - 18197041
AN - SCOPUS:38149135882
SN - 1040-8703
VL - 20
SP - 62
EP - 66
JO - Current opinion in pediatrics
JF - Current opinion in pediatrics
IS - 1
ER -