Hstopathological features of L-asparaginase-induced liver disease

Sunati Sahoo, John Hart

Research output: Contribution to journalReview articlepeer-review

57 Scopus citations


We studied the histopathological changes of liver in four patients who developed hepatomegaly and abnormal liver chemistry tests 2 to 20 days following administration of L-asparaginase as a part of a combination chemotherapy regimen for treatment of acute lymphoblastic leukemia. The severity of the liver disease due to L-asparaginase was unpredictable. One patient developed acute fulminant hepatic failure and required liver transplantation. The most consistent pathological change, observed in all four cases, was diffuse steatosis. Other changes included patchy hepatocyte necrosis, mixed inflammatory cell infiltrates in the portal tracts, and variable degrees of hepatocellular, or canalicular cholestasis, or a combination of these.

Original languageEnglish (US)
Pages (from-to)295-299
Number of pages5
JournalSeminars in liver disease
Issue number3
StatePublished - Aug 1 2003


  • Drug-induced liver disease
  • L-asparaginase toxity
  • Steatosis

ASJC Scopus subject areas

  • Hepatology


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