@article{208ffdec3ea544e08ac165d057fc91df,
title = "HSP70 promotes MLKL polymerization and necroptosis",
abstract = "Mixed lineage kinase domain-like protein (MLKL) is the proposed executioner of necroptosis. Our recent findings identify a novel inhibitor necroptosis-blocking compound 1 (NBC1) which specifically conjugates to two cysteines of heat shock protein 70 (HSP70) to block its function. Importantly, HSP70 promotes MLKL polymerization to activate necroptosis.",
keywords = "HSP70, MLKL, Necroptosis, regulated cell death",
author = "Johnston, {Andrea N.} and Zhigao Wang",
note = "Funding Information: This work was supported by grants from the Welch Foundation (I1827) and National Institute of General Medical Sciences (NIGMS) (R01, RGM120502A) to Z.W. and fellowship to A.N.J. (2T32GM008203-26A1). Z.W. is the Virginia Murchison Linthicum Scholar in Medical Research and Cancer Prevention and Research Institute of Texas Scholar (R1222). Publisher Copyright: {\textcopyright} 2020, {\textcopyright} 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.",
year = "2020",
doi = "10.1080/23723556.2020.1791561",
language = "English (US)",
journal = "Molecular and Cellular Oncology",
issn = "2372-3556",
publisher = "Taylor and Francis Ltd.",
}