Abstract
Eukaryotic cells can repair many types of DNA damage. Among the known DNA repair processes in humans, one type - nucleotide excision repair (NER) - specifically protects against mutations caused indirectly by environmental carcinogens. Humans with a hereditary defect in NER suffer from xeroderma pigmentosum and have a marked predisposition to skin cancer caused by sunlight exposure. How does NER protect against skin cancer and possibly other types of environmentally induced cancer in humans?
Original language | English (US) |
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Pages (from-to) | 22-33 |
Number of pages | 12 |
Journal | Nature Reviews Cancer |
Volume | 1 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1 2001 |
ASJC Scopus subject areas
- Oncology
- Cancer Research