Host-Range Properties of Murine Xenotropic and Ecotropic Type-C Viruses

H. K. Oie, E. K. Russell, J. H. Dotson, J. M. Rhoads, A. F. Gazdar

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Host-range properties of xenotropic (x-tropic) and ecotropic mouse type-C viruses were determined. NB-tropic viruses replicated only in mouse and rat cells, whereas x-tropic viruses, which do not exogenously infect mouse cells, grew in cells from various other mammalian species. Great variability in susceptibilities to x-tropic viruses was demonstrated in cells frOm heterologous species and in cells from a single species (human). Although rat cells were susceptible to both types of viruses, hamster cells were uniformly resistant. In addition, the x-tropic viruses crossed class barriers to infect cells of avian species but not insect, fish, or reptile cells.—J Natl Cancer Inst 56: 423-426, 1976.

Original languageEnglish (US)
Pages (from-to)423-426
Number of pages4
JournalJournal of the National Cancer Institute
Issue number2
StatePublished - Feb 1976

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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