TY - JOUR
T1 - Hospitalized hemorrhagic stroke patients with renal insufficiency
T2 - Clinical characteristics, care patterns, and outcomes
AU - Ovbiagele, Bruce
AU - Schwamm, Lee H.
AU - Smith, Eric E.
AU - Grau-Sepulveda, Maria V.
AU - Saver, Jeffrey L.
AU - Bhatt, Deepak L.
AU - Hernandez, Adrian F.
AU - Peterson, Eric D.
AU - Fonarow, Gregg C.
N1 - Funding Information:
The Get With the Guidelines Program (GWTG) is funded by the American Heart Association and the American Stroke Association . The program is also supported in part by unrestricted educational grants to the American Heart Association by Pfizer (New York, NY) and the Merck-Schering Plough Partnership (North Wales, PA), who did not participate in the design, analysis, or article preparation, and did not require approval of this article for submission.
Publisher Copyright:
© 2014 National Stroke Association.
PY - 2014/10/1
Y1 - 2014/10/1
N2 - Background: There is a paucity of information on clinical characteristics, care patterns, and clinical outcomes for hospitalized intracerebral hemorrhage (ICH) patients with chronic kidney disease (CKD). We assessed characteristics, care processes, and in-hospital outcome among ICH patients with CKD in the Get With the Guidelines-Stroke (GWTG-Stroke) program.Methods: We analyzed 113,059 ICH patients hospitalized at 1472 US centers participating in the GWTGStroke program between January 2009 and December 2012. In-hospital mortality and use of 2 predefined ICH performance measures were examined based on glomerular filtration rate. Renal dysfunction was categorized as a dichotomous (1CKD 5 estimated glomerular filtration rate<60) or rank ordered variable as CKD (<60), and by clinical stage: (normal [≥90], mild [≥60 -<90], moderate [≥30<60], severe [≥15<30], and/or kidney failure [<15 or dialysis]).Results: There were 33,219 (29%) ICH patients with CKD. Patients with CKD were more likely to be older, female, and with comorbid conditions such as diabetes. Compared with patients with normal kidney function, those with CKD were slightly less likely to receive deep venous thrombosis (DVT) prophylaxis but similarly received discharge smoking cessation intervention. Inpatient mortality was also higher for those with CKD (adjusted odds ratio [OR], 1.47; 95% confidence interval [CI], 1.42-1.52), mild dysfunction (adjusted OR, 1.12; 95% CI, 1.08-1.16), moderate dysfunction (adjusted OR, 1.46; 95% CI, 1.39-1.53), severe dysfunction (adjusted OR, 1.96; 95% CI, 1.81-2.12), and kidney failure (adjusted OR, 2.22; 95% CI, 2.04-2.43) relative to those with normal renal function.Conclusions: Chronic kidney disease is present in nearly a third of patients hospitalized with ICH and is associated with slightly worse care and substantially higher mortality than those with normal renal function.
AB - Background: There is a paucity of information on clinical characteristics, care patterns, and clinical outcomes for hospitalized intracerebral hemorrhage (ICH) patients with chronic kidney disease (CKD). We assessed characteristics, care processes, and in-hospital outcome among ICH patients with CKD in the Get With the Guidelines-Stroke (GWTG-Stroke) program.Methods: We analyzed 113,059 ICH patients hospitalized at 1472 US centers participating in the GWTGStroke program between January 2009 and December 2012. In-hospital mortality and use of 2 predefined ICH performance measures were examined based on glomerular filtration rate. Renal dysfunction was categorized as a dichotomous (1CKD 5 estimated glomerular filtration rate<60) or rank ordered variable as CKD (<60), and by clinical stage: (normal [≥90], mild [≥60 -<90], moderate [≥30<60], severe [≥15<30], and/or kidney failure [<15 or dialysis]).Results: There were 33,219 (29%) ICH patients with CKD. Patients with CKD were more likely to be older, female, and with comorbid conditions such as diabetes. Compared with patients with normal kidney function, those with CKD were slightly less likely to receive deep venous thrombosis (DVT) prophylaxis but similarly received discharge smoking cessation intervention. Inpatient mortality was also higher for those with CKD (adjusted odds ratio [OR], 1.47; 95% confidence interval [CI], 1.42-1.52), mild dysfunction (adjusted OR, 1.12; 95% CI, 1.08-1.16), moderate dysfunction (adjusted OR, 1.46; 95% CI, 1.39-1.53), severe dysfunction (adjusted OR, 1.96; 95% CI, 1.81-2.12), and kidney failure (adjusted OR, 2.22; 95% CI, 2.04-2.43) relative to those with normal renal function.Conclusions: Chronic kidney disease is present in nearly a third of patients hospitalized with ICH and is associated with slightly worse care and substantially higher mortality than those with normal renal function.
KW - Chronic kidney disease
KW - glomerular filtration rate
KW - guidelines
KW - hemorrhagic stroke
KW - outcomes
KW - prognosis
KW - quality indicators
KW - renal
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U2 - 10.1016/j.jstrokecerebrovasdis.2014.04.016
DO - 10.1016/j.jstrokecerebrovasdis.2014.04.016
M3 - Article
C2 - 25158677
AN - SCOPUS:84908006817
SN - 1052-3057
VL - 23
SP - 2265
EP - 2273
JO - Journal of Stroke and Cerebrovascular Diseases
JF - Journal of Stroke and Cerebrovascular Diseases
IS - 9
ER -