@article{0ec05aae3954498f8553ac1a8e2b7d5d,
title = "HIV-Positive Liver Transplant Does not Alter the Latent Viral Reservoir in Recipients With Antiretroviral Therapy-Suppressed HIV",
abstract = "The latent viral reservoir (LVR) remains a major barrier to HIV-1 curative strategies. It is unknown whether receiving a liver transplant from a donor with HIV might lead to an increase in the LVR because the liver is a large lymphoid organ. We found no differences in intact provirus, defective provirus, or the ratio of intact to defective provirus between recipients with ART-suppressed HIV who received a liver from a donor with (n = 19) or without HIV (n = 10). All measures remained stable from baseline by 1 year posttransplant. These data demonstrate that the LVR is stable after liver transplantation in people with HIV.",
keywords = "HIV, HIV cure, latent viral reservoir, liver, organ transplant",
author = "Benner, {Sarah E.} and Xianming Zhu and Sarah Hussain and Sander Florman and Yolanda Eby and Fernandez, {Reinaldo E.} and Darin Ostrander and Meenakshi Rana and Shane Ottmann and Jonathan Hand and Price, {Jennifer C.} and Pereira, {Marcus R.} and David Wojciechowski and Jacques Simkins and Valentina Stosor and Mehta, {Sapna A.} and Saima Aslam and Maricar Malinis and Ghady Haidar and Allan Massie and Smith, {Melissa L.} and Jonah Odim and Megan Morsheimer and Quinn, {Thomas C.} and Laird, {Gregory M.} and Robert Siliciano and Ashwin Balagopal and Segev, {Dorry L.} and Durand, {Christine M.} and Redd, {Andrew D.} and Tobian, {Aaron A.R.}",
note = "Publisher Copyright: {\textcopyright} The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Societ of America.",
year = "2023",
month = nov,
day = "1",
doi = "10.1093/infdis/jiad241",
language = "English (US)",
volume = "228",
pages = "1274--1279",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "9",
}