HIV and CXCR4 in a kiss of autophagic death

Beth Levine, Donald L. Sodora

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


AIDS is characterized by CD4+ T lymphocyte depletion, yet the mechanisms underlying this central aspect of HIV pathogenesis are still poorly understood. In this issue of the JCI, Espert et al. identify a mechanism by which the HIV envelope glycoprotein can induce death in uninfected CD4 + T cells (see the related article beginning on page 2161). The HIV envelope glycoprotein interacts with CXC chemokine receptor 4 to activate the lysosomal degradation pathway of autophagy, which is necessary for both apoptotic and non-apoptotic cell death.

Original languageEnglish (US)
Pages (from-to)2078-2080
Number of pages3
JournalJournal of Clinical Investigation
Issue number8
StatePublished - Aug 1 2006

ASJC Scopus subject areas

  • General Medicine


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