Highlights in ASCVD Primary Prevention for 2021

Tamar S. Polonsky, Amit Khera, Michael D. Miedema, Douglas D. Schocken, Peter W.F. Wilson

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


This review examines key studies published in 2021 that are related to primary prevention of atherosclerotic cardiovascular disease (ASCVD). Major randomized clinical trials (RCTs) concerning traditional risk factors or ASCVD events, meta-analyses, and key observational studies related to primary prevention of ASCVD were considered. The review includes interventions for weight loss, cardiometabolic and renal disease, blood pressure control, diet, and the occurrence of cardiovascular disease events. A few studies considered both primary and secondary prevention populations. The review is not exhaustive. We did not include studies that focused on heart failure or clinical presentations that may be difficult to classify, such as acute or chronic ischemic cardiovascular disease without myocardial infarction. Our purpose was to highlight recent research that will help the reader stay abreast of the changing field of cardiovascular prevention.

Original languageEnglish (US)
Article numbere25973
JournalJournal of the American Heart Association
Issue number13
StatePublished - Jul 5 2022


  • diabetes
  • hypertension
  • obesity
  • primary prevention
  • risk factors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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