High Ubiquitin-Specific Protease 2a Expression Level Predicts Poor Prognosis in Upper Tract Urothelial Carcinoma

Hung Lung Ke, Yi Chen Lee, Wei Ming Li, Chien Sheng Wang, Wei Chi Hsu, Hui Hui Lin, Yu An Lee, Jhen Hao Jhan, Ching Chia Li, Hsin Chih Yeh, Wen Jeng Wu, A. Mei Huang

Research output: Contribution to journalArticlepeer-review


Background: Ubiquitin-mediated protein degradation has been reported to be involved in regulating the activity of oncoproteins and tumor suppressors. Dysfunction or dysregulation of the ubiquitin-proteasome system may induce tumorigenesis. Deubiquitinase ubiquitin-specific protease 2a (USP2a) has been reported to regulate cell growth or death and is involved in the pathogenesis of various diseases, including cancers. However, the role of USP2a in upper tract urothelial carcinoma (UTUC) has not been investigated yet. The goal of this study was to evaluate the clinical significance of USP2a expression in UTUC. Materials and Methods: A total of 110 UTUC cases were included in this study. USP2a expression level was evaluated through immunohistochemistry staining, and the correlation of USP2a expression level with both clinical and pathologic variables was analyzed. Results: High USP2a expression level was observed in 48 (43.6%) cancer specimens. USP2a expression level was significantly correlated with tumor stage (P=0.001), grade (P=0.033), and tumor recurrence (P=0.008). High USP2a expression level was correlated with poor disease-free survival (P=0.005) and cancer-specific survival (P<0.001). In addition, high USP2a expression level was an independent predictor of poor disease-free survival (hazard ratio=2.31; P=0.007) and cancer-specific survival (hazard ratio=5.49; P=0.009). Conclusions: This study indicated that USP2a protein expression level may be a potential biomarker for predicting UTUC patient survival. Further prospective studies are needed to investigate the role of USP2a in UTUC progression.

Original languageEnglish (US)
Pages (from-to)304-310
Number of pages7
JournalApplied Immunohistochemistry and Molecular Morphology
Issue number4
StatePublished - Apr 1 2022
Externally publishedYes


  • immunohistochemistry
  • survival
  • ubiquitin-specific protease 2a
  • upper tract urothelial carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Medical Laboratory Technology


Dive into the research topics of 'High Ubiquitin-Specific Protease 2a Expression Level Predicts Poor Prognosis in Upper Tract Urothelial Carcinoma'. Together they form a unique fingerprint.

Cite this