High levels of intracellular bombesin characterize human small-cell lung carcinoma

Terry W. Moody; Candace B. Pert; Adi F. Gazdar; Desmond N. Carney; John D. Minna

doi:10.1126/science.6272398

High levels of intracellular bombesin characterize human small-cell lung carcinoma

Terry W. Moody, Candace B. Pert, Adi F. Gazdar, Desmond N. Carney, John D. Minna

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Abstract

"Small cells" or "oat cells" characterize a virulent form of lung cancer and share many biochemical properties with peptide-secreting neurones. The neuropeptide bombesin is present in all small-cell lines examined, but not in other lung cancer cell lines, suggesting that bombesinergic precursor cells in lung may give rise to this disease.

Original language	English (US)
Pages (from-to)	1246-1248
Number of pages	3
Journal	Science
Volume	214
Issue number	4526
DOIs	https://doi.org/10.1126/science.6272398
State	Published - Jan 1 1981

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title = "High levels of intracellular bombesin characterize human small-cell lung carcinoma",

abstract = "{"}Small cells{"} or {"}oat cells{"} characterize a virulent form of lung cancer and share many biochemical properties with peptide-secreting neurones. The neuropeptide bombesin is present in all small-cell lines examined, but not in other lung cancer cell lines, suggesting that bombesinergic precursor cells in lung may give rise to this disease.",

author = "Moody, {Terry W.} and Pert, {Candace B.} and Gazdar, {Adi F.} and Carney, {Desmond N.} and Minna, {John D.}",

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AU - Pert, Candace B.

AU - Gazdar, Adi F.

AU - Carney, Desmond N.

AU - Minna, John D.

PY - 1981/1/1

Y1 - 1981/1/1

N2 - "Small cells" or "oat cells" characterize a virulent form of lung cancer and share many biochemical properties with peptide-secreting neurones. The neuropeptide bombesin is present in all small-cell lines examined, but not in other lung cancer cell lines, suggesting that bombesinergic precursor cells in lung may give rise to this disease.

AB - "Small cells" or "oat cells" characterize a virulent form of lung cancer and share many biochemical properties with peptide-secreting neurones. The neuropeptide bombesin is present in all small-cell lines examined, but not in other lung cancer cell lines, suggesting that bombesinergic precursor cells in lung may give rise to this disease.

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High levels of intracellular bombesin characterize human small-cell lung carcinoma

Abstract

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