High-field proton magnetic resonance spectroscopy of a swine model for axonal injury

Kim M. Cecil, Robert E. Lenkinski, David F. Meaney, Tracy K. McIntosh, Douglas H. Smith

Research output: Contribution to journalArticlepeer-review

69 Scopus citations


A miniature swine model for diffuse brain injury has recently been developed that replicates the inertial loading conditions associated with rotational acceleration during automotive accidents. The swine model induces diffuse axonal pathology without macroscopic injury such as contusions and hematomas, thus affording a unique opportunity to study axonal injury with noninvasive techniques such as magnetic resonance imaging (MRI) and spectroscopy (MRS). In the present study, we evaluated this diffuse injury model with proton MRS, in vivo, using a high-field (4.0-T) MR scanner, since MRS has been demonstrated as a sensitive probe for detecting neuro-chemical abnormalities. Our study examined a region of the swine brain at timepoints before and after brain injury. Spectroscopic results indicate that N- acetylaspartate/creatine is diminished by at least 20% in regions of confirmed axonal pathology, whereas conventional MRI did not detect any abnormalities. These findings suggest that MRS has high sensitivity in diagnosing microscopic pathology following diffuse brain injury.

Original languageEnglish (US)
Pages (from-to)2038-2044
Number of pages7
JournalJournal of Neurochemistry
Issue number5
StatePublished - May 1998


  • Diffuse axonal injury
  • N-Acetylaspartate
  • Spectroscopy

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience


Dive into the research topics of 'High-field proton magnetic resonance spectroscopy of a swine model for axonal injury'. Together they form a unique fingerprint.

Cite this