High cardiovascular event rates in patients with asymptomatic carotid stenosis: The REACH registry

F. T. Aichner, R. Topakian, M. J. Alberts, D. L. Bhatt, H. P. Haring, M. D. Hill, G. Montalescot, S. Goto, E. Touzé, J. L. Mas, P. G. Steg, J. Röther

Research output: Contribution to journalArticlepeer-review

59 Scopus citations


Background and purpose: Data on current cardiovascular event rates in patients with asymptomatic carotid artery stenosis (ACAS) are sparse. We compared the 1-year outcomes of patients with ACAS ≥70% versus patients without ACAS in an international, prospective cohort of outpatients with or at risk of atherothrombosis. Methods: The Reduction of Atherothrombosis for Continued Health Registry enrolled patients with either ≥3 atherothrombotic risk factors or established atherothrombotic disease. We investigated the 1-year follow-up data of patients for whom physicians reported presence/absence of ACAS at the time of inclusion. Results: Compared with patients without ACAS (n = 30 329), patients with ACAS (n = 3164) had higher age- and sex-adjusted 1-year rates of transient ischaemic attack (3.51% vs. 1.61%, P < 0.0001), non-fatal stroke (2.65% vs. 1.75%, P = 0.0009), fatal stroke (0.49% vs. 0.26%, P = 0.04), cardiovascular death (2.29% vs. 1.52%, P = 0.002), the composite end-point cardiovascular death/myocardial infarction/stroke (6.03% vs. 4.29%, P < 0.0001) and bleeding events (1.41% vs. 0.81%, P = 0.002). In patients with ACAS, Cox regression analyses identified history of cerebrovascular ischaemic events as most important predictor of future stroke (HR 3.21, 95% CI 1.82-5.65, P < 0.0001). Conclusion: Asymptomatic carotid artery stenosis was associated with high 1-year rates of cardiovascular and cerebrovascular ischaemic events. Stroke was powerfully predicted by prior cerebrovascular ischaemic events.

Original languageEnglish (US)
Pages (from-to)902-908
Number of pages7
JournalEuropean Journal of Neurology
Issue number8
StatePublished - Aug 2009


  • Carotid artery stenosis
  • Outcome assessment
  • Prevention
  • Stroke
  • Therapy

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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