High and ultra-high resolution metabolite mapping of the human brain using 1H FID MRSI at 9.4T

Sahar Nassirpour, Paul Chang, Anke Henning

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


Magnetic resonance spectroscopic imaging (MRSI) is a promising technique for mapping the spatial distribution of multiple metabolites in the human brain. These metabolite maps can be used as a diagnostic tool to gain insight into several biochemical processes and diseases in the brain. In comparison to lower field strengths, MRSI at ultra-high field strengths benefits from a higher signal to noise ratio (SNR) as well as higher chemical shift dispersion, and hence spectral resolution. This study combines the benefits of an ultra-high field magnet with the advantages of an ultra-short TE and TR single-slice FID-MRSI sequence (such as negligible J-evolution and loss of SNR due to T2 relaxation effects) and presents the first metabolite maps acquired at 9.4 T in the healthy human brain at both high (voxel size of 97.6 µL) and ultra-high (voxel size of 24.4 µL) spatial resolutions in a scan time of 11 and 46 min respectively. In comparison to lower field strengths, more anatomically-detailed maps with higher SNR from a larger number of metabolites are shown. A total of 12 metabolites including glutamate (Glu), glutamine (Gln), N-acetyl-aspartyl-glutamate (NAAG), Gamma-aminobutyric acid (GABA) and glutathione (GSH) are reliably mapped. Comprehensive description of the methodology behind these maps is provided.

Original languageEnglish (US)
Pages (from-to)211-221
Number of pages11
StatePublished - Mar 2018
Externally publishedYes


  • 9.4 T
  • Human brain
  • Metabolite mapping
  • Spectroscopic imaging
  • Ultra-high magnetic field

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience


Dive into the research topics of 'High and ultra-high resolution metabolite mapping of the human brain using 1H FID MRSI at 9.4T'. Together they form a unique fingerprint.

Cite this