Heterodyne frequency-domain multispectral diffuse optical tomography of breast cancer in the parallel-plane transmission geometry

H. Y. Ban, M. Schweiger, V. C. Kavuri, J. M. Cochran, L. Xie, D. R. Busch, J. Katrašnik, S. Pathak, S. H. Chung, K. Lee, R. Choe, B. J. Czerniecki, S. R. Arridge, A. G. Yodh

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Purpose: The authors introduce a state-of-the-art all-optical clinical diffuse optical tomography (DOT) imaging instrument which collects spatially dense, multispectral, frequency-domain breast data in the parallel-plate geometry. Methods: The instrument utilizes a CCD-based heterodyne detection scheme that permits massively parallel detection of diffuse photon density wave amplitude and phase for a large number of sourcedetector pairs (106). The stand-alone clinical DOT instrument thus offers high spatial resolution with reduced crosstalk between absorption and scattering. Other novel features include a fringe profilometry system for breast boundary segmentation, real-time data normalization, and a patient bed design which permits both axial and sagittal breast measurements. Results: The authors validated the instrument using tissue simulating phantoms with two different chromophore-containing targets and one scattering target. The authors also demonstrated the instrument in a case study breast cancer patient; the reconstructed 3D image of endogenous chromophores and scattering gave tumor localization in agreement with MRI. Conclusions: Imaging with a novel parallel-plate DOT breast imager that employs highly parallel, high-resolution CCD detection in the frequency-domain was demonstrated.

Original languageEnglish (US)
Pages (from-to)4383-4395
Number of pages13
JournalMedical physics
Issue number7
StatePublished - Jul 1 2016
Externally publishedYes


  • CCD-based optical tomography instrumentation
  • breast cancer imaging
  • diffuse optical tomography
  • optical mammography

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging


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