TY - JOUR
T1 - Herpes simplex virus infection is sensed by both Toll-like receptors and retinoic acid-inducible genelike receptors, which synergize to induce type I interferon production
AU - Rasmussen, Simon B.
AU - Jensen, Søren B.
AU - Nielsen, Christoffer
AU - Quartin, Emanuel
AU - Kato, Hiroki
AU - Chen, Zhijian J.
AU - Silverman, Robert H.
AU - Akira, Shizuo
AU - Paludan, Søren R.
PY - 2009
Y1 - 2009
N2 - The innate antiviral response is initiated by pattern recognition receptors, which recognize viral pathogen-associated molecular patterns. Here we show that retinoic acid-inducible gene (RIG)-I-like receptors (RLRs) in cooperation with Toll-like receptor (TLR) 9 is required for expression of type I interferons (IFNs) after infection with herpes simplex virus (HSV). Our work also identified RNase L as a critical component in IFN induction. Moreover, we found that TLR9 and RLRs activate distinct, as well as overlapping, intracellular signalling pathways. Thus, RLRs are important for recognition of HSV infection, and cooperate with the Toll pathway to induce an antiviral response.
AB - The innate antiviral response is initiated by pattern recognition receptors, which recognize viral pathogen-associated molecular patterns. Here we show that retinoic acid-inducible gene (RIG)-I-like receptors (RLRs) in cooperation with Toll-like receptor (TLR) 9 is required for expression of type I interferons (IFNs) after infection with herpes simplex virus (HSV). Our work also identified RNase L as a critical component in IFN induction. Moreover, we found that TLR9 and RLRs activate distinct, as well as overlapping, intracellular signalling pathways. Thus, RLRs are important for recognition of HSV infection, and cooperate with the Toll pathway to induce an antiviral response.
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U2 - 10.1099/vir.0.005389-0
DO - 10.1099/vir.0.005389-0
M3 - Article
C2 - 19088275
AN - SCOPUS:59849100923
SN - 0022-1317
VL - 90
SP - 74
EP - 78
JO - Journal of General Virology
JF - Journal of General Virology
IS - 1
ER -