Hepatocyte growth factor/scatter factor modulates intestinal epithelial cell proliferation and migration

A. U. Dignass, K. Lynchdevaney, D. K. Podolsky

Research output: Contribution to journalArticlepeer-review

142 Scopus citations


Various peptide growth factors have been found to regulate epithelial cell function within the mucosal epithelium of the gastrointestinal tract. In this study hepatocyte growth factor/scatter factor (HGF/SF) was found to stimulate intestinal epithelial cell proliferation: 2.5-fold in the non-transformed rat small intestinal epithelial cell line IEC-6 and 1.9-fold in the human colon cancer-derived HT-29 cell line. In addition, HGF/SF enhanced epithelial cell restitution, the initial step involved in gastrointestinal wound healing, in an invitro model. Migration of IEC-6 in wounded monolayers was enhanced up to 7-fold. Enhancement of restitution by HGF could be completely abrogated by addition of immunoneutralizing anti-TGFβ1, indicating that this process is mediated through a TGFβ-dependent pathway. These findings suggest that HGF exerts functional effects on intestinal epithelial cell populations and may play a role in the morphogenesis tract and its remodeling following injury.

Original languageEnglish (US)
Pages (from-to)701-709
Number of pages9
JournalBiochemical and Biophysical Research Communications
Issue number2
StatePublished - Jul 29 1994

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


Dive into the research topics of 'Hepatocyte growth factor/scatter factor modulates intestinal epithelial cell proliferation and migration'. Together they form a unique fingerprint.

Cite this