Hepatitis C Infection Associated with Acquired Pure Red Cell Aplasia

Destini Teague, Carmelo Gurnari, Hussein Awada, Jaroslaw P. Maciejewski, Ibrahim F Ibrahim, Taha Bat

Research output: Contribution to journalArticlepeer-review

Abstract

Acquired pure red cell aplasia is a rare bone marrow failure disorder characterized by many underlying etiologies. The hallmark bone marrow feature is the near absence of erythroid precursors that otherwise exhibit normal cellularity, which has been attributed to both immune- and cellular-mediated mechanisms. Besides being merely speculative and considering the rarity of the disorder, the description of acquired pure red cell aplasia clinical associations represents a unique occasion to improve our current clinical knowledge of the disease, reveal clues on its pathogenesis, and guide therapeutic decisions. The varied clinical scenarios and common acquired pure red cell aplasia associated conditions (i.e., thymoma, T cell/NK-cell large granular lymphocyte leukemia, B cell dyscrasia) suggest a heterogeneity of pathogenic routes. Viral etiologies must always be considered and worked up in the initial assessment of newly diagnosed acquired pure red cell aplasia patients. In this report, we present two cases of hepatitis-C-related acquired pure red cell aplasia and successful use of anti-viral strategies in the achievement of a complete response.

Original languageEnglish (US)
Article number8
JournalTropical Medicine and Infectious Disease
Volume8
Issue number1
DOIs
StatePublished - Jan 2023

Keywords

  • bone marrow failure syndromes
  • HCV
  • pure red cell aplasia

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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