Hemorrhagic-ischemic cerebral injury in the preterm infant: Current concepts

Lina Shalak, Jeffrey M. Perlman

Research output: Contribution to journalReview articlepeer-review

56 Scopus citations


PV-IVH and adjacent white matter injury remains a significant problem in the premature infant. The potential mechanisms contributing to injury are complex and involve factors related to blood flow and its regulation, as well as cellular mediators including cytokines, free radical formation, and excitotoxin release. Although a reduction in the occurrence of severe IVH can be achieved with indomethacin, it does translate into long-term neurodevelopmental benefit. This reinforces the concept of a more diffuse injury to brain in sick premature infants than is apparent from the appearance of current neuroimaging techniques.

Original languageEnglish (US)
Pages (from-to)745-763
Number of pages19
JournalClinics in Perinatology
Issue number4
StatePublished - Dec 2002

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


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