Hemodynamic evaluation of the carpentier-edwards bioprosthesis in the aortic position

Michael Rothkopf, Thomas Davidson, Kirk Lipscomb, Kenneth Narahara, L. David Hillis, James T. Willerson, Aaron Estrera, Melvin Platt, Lawrence Mills

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


The Carpentier-Edwards bioprosthesis is a glutaraldehyde-fixed porcine xenograft with a fully flexible thin-walled stent. Cardiac catheterization studies were performed in 17 patients to evaluate use of this valve in the aortic position. Hemodynamic studies established a mean peak gradient across the prosthesis of 19 mm Hg (range 5 to 65). The mean effective orifice area was calculated to be 1.6 cm2 (range 0.8 to 3.3). All patients demonstrated an improvement in functional class after operation. Mean left ventricular ejection fraction increased from 51 ± 16 to 68 ± 9 percent (P < 0.004) in eight patients operated on for aortic stenosis, but was not significantly changed in patients operated on for aortic insufficiency. Hemodynamic comparison of the Carpentier-Edwards bioprosthesis with the standard Hancock xenograft showed similar effective orifice areas for the 23 and 25 mm diameter valves. In two patients studied the 21 mm Carpentier valve demonstrated a greater effective orifice area than that previously reported for the standard Hancock xenograft. The Carpentier-Edwards bioprosthesis affords both clinical and hemodynamic improvement when used in the aortic position and may allow improved effective orifice area when used in the smaller aortic root.

Original languageEnglish (US)
Pages (from-to)209-214
Number of pages6
JournalThe American journal of cardiology
Issue number2
StatePublished - Aug 1979

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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