Helicobacter pylori seroprevalence in symptomatic veterans: A study of 7310 patients over 11 years

Susanne W. Carmack, Robert M. Genta

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Background and Aims: The prevalence of Helicobacter pylori infection has been decreasing in the USA, but recent data are lacking. This study evaluates the seroprevalence for anti-H. pylori antibodies in symptomatic veterans tested over the past 11 years. Materials and Methods: The same serum anti-H. pylori IgG detection system has been used at a tertiary care Veterans Affairs hospital since late 1996. Results of all tests performed from 1997 to 2007 were analyzed. Results: Of 7310 unique patients tested, 3982 (54.5%) were positive. Seropositivity declined from 70.8% in 1997 to 48.6% in 2002, then reached a plateau around 50%. A strong birth cohort effect was present, from a seropositivity of 72.7% for the veterans born before 1920 to 22% for those born between after 1980. Conclusions: Despite a constant birth cohort effect, H. pylori seropositivity among symptomatic veterans leveled down at ∼50% after declining steadily from 1997 to 2002.

Original languageEnglish (US)
Pages (from-to)298-302
Number of pages5
Issue number4
StatePublished - Aug 1 2009


  • Epidemiology
  • Helicobacter pylori
  • Serology
  • Veterans

ASJC Scopus subject areas

  • Gastroenterology
  • Infectious Diseases


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