Hedgehog Signaling in Development and Cancer

Jin Jiang; Chi chung Hui

doi:10.1016/j.devcel.2008.11.010

Hedgehog Signaling in Development and Cancer

Jin Jiang, Chi chung Hui

Research output: Contribution to journal › Review article › peer-review

885 Scopus citations

Abstract

The Hedgehog (Hh) family of secreted proteins governs a wide variety of processes during embryonic development and adult tissue homeostasis. Here we review the current understanding of the molecular and cellular basis of Hh morphogen gradient formation and signal transduction, and the multifaceted roles of Hh signaling in development and tumorigenesis. We discuss how the Hh pathway has diverged during evolution and how it integrates with other signaling pathways to control cell growth and patterning.

Original language	English (US)
Pages (from-to)	801-812
Number of pages	12
Journal	Developmental cell
Volume	15
Issue number	6
DOIs	https://doi.org/10.1016/j.devcel.2008.11.010
State	Published - Dec 9 2008

ASJC Scopus subject areas

Molecular Biology
General Biochemistry, Genetics and Molecular Biology
Developmental Biology
Cell Biology

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10.1016/j.devcel.2008.11.010

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@article{6106b756284b4d62bf988831c3e49fe7,

title = "Hedgehog Signaling in Development and Cancer",

abstract = "The Hedgehog (Hh) family of secreted proteins governs a wide variety of processes during embryonic development and adult tissue homeostasis. Here we review the current understanding of the molecular and cellular basis of Hh morphogen gradient formation and signal transduction, and the multifaceted roles of Hh signaling in development and tumorigenesis. We discuss how the Hh pathway has diverged during evolution and how it integrates with other signaling pathways to control cell growth and patterning.",

author = "Jin Jiang and Hui, {Chi chung}",

note = "Funding Information: We thank Keith Wharton, Brian Ciruna, and Stephane Angers, and members of the Jiang and Hui laboratories for comments. We apologize to colleagues whose original researches on many aspects of Hh signaling were not cited due to space limitations. J.J. is supported by grants from NIH, Leukemia and Lymphoma Society Scholar Program, and Welch Foundation, and C.-C.H. is supported by National Cancer Institute of Canada.",

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doi = "10.1016/j.devcel.2008.11.010",

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AU - Jiang, Jin

AU - Hui, Chi chung

N1 - Funding Information: We thank Keith Wharton, Brian Ciruna, and Stephane Angers, and members of the Jiang and Hui laboratories for comments. We apologize to colleagues whose original researches on many aspects of Hh signaling were not cited due to space limitations. J.J. is supported by grants from NIH, Leukemia and Lymphoma Society Scholar Program, and Welch Foundation, and C.-C.H. is supported by National Cancer Institute of Canada.

PY - 2008/12/9

Y1 - 2008/12/9

N2 - The Hedgehog (Hh) family of secreted proteins governs a wide variety of processes during embryonic development and adult tissue homeostasis. Here we review the current understanding of the molecular and cellular basis of Hh morphogen gradient formation and signal transduction, and the multifaceted roles of Hh signaling in development and tumorigenesis. We discuss how the Hh pathway has diverged during evolution and how it integrates with other signaling pathways to control cell growth and patterning.

AB - The Hedgehog (Hh) family of secreted proteins governs a wide variety of processes during embryonic development and adult tissue homeostasis. Here we review the current understanding of the molecular and cellular basis of Hh morphogen gradient formation and signal transduction, and the multifaceted roles of Hh signaling in development and tumorigenesis. We discuss how the Hh pathway has diverged during evolution and how it integrates with other signaling pathways to control cell growth and patterning.

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DO - 10.1016/j.devcel.2008.11.010

M3 - Review article

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VL - 15

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JO - Developmental cell

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Hedgehog Signaling in Development and Cancer

Abstract

ASJC Scopus subject areas

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