Health-related quality of life in patients with multiple injuries and traumatic brain injury 10+ years postinjury

Jennifer Steel, Michael Youssef, Roman Pfeifer, Juliana M. Ramirez, Christian Probst, Richard Sellei, Boris A. Zelle, Nicola Alexander Sittaro, Farah Khalifa, Hans Christoph Pape

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Background: The aim of this study was to examine the long-term physical and psychological consequences of multiple blunt forced trauma at ≥10-year follow-up for patients with and without traumatic brain injury (Tbi). Methods: A total of 620 patients with multiple injuries were assessed with the Medical Outcomes Study-Short Form-12 and a physical reexamination at ≥10-year follow-up. Injury-related characteristics were collected from patients' medical record. Chi-square analysis, Analysis of Variance, and linear and logistic regression were performed to test differences between groups and examine predictors of physical and psychological functioning at ≥10-year follow-up. Results: Patients with multiple injuries who sustained a TBI (n = 398) were more likely to be female (p = 0.001), younger in age at the time of injury (p = 0.02), have higher Injury Severity Scores (p = 0.001), shorter ward stays (p = 0.001), and a greater number of upper extremity injuries (p = 0.02) when compared with those without TBI (n = 222). Patients with TBI reported poorer psychological functioning (p = 0.02) and more frequently reported chronic pain (p = 0.01). Patients with TBI used medical aids (p = 0.002) less frequently at follow-up when compared with patients without TBI. Significant predictors of health-related quality of life at ≥10-year follow-up included age at the time of injury (physical; p = 0.001), gender (p = 0.05), number of ventilation days (p = 0.02), satisfaction with rehabilitation (p = 0.001), disability caused by the injury (p = 0.001), and use of medical aids (physical p = 0.02). Conclusions: Prospective studies are needed with a broader range of measures that may be sensitive to the consequences of TBI. Evidence-based interventions to facilitate physical and psychological rehabilitation, designed to target at risk patients, are warranted.

Original languageEnglish (US)
Pages (from-to)523-530
Number of pages8
JournalJournal of Trauma - Injury, Infection and Critical Care
Issue number3
StatePublished - Sep 2010
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Critical Care and Intensive Care Medicine


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