Has first-line therapy had an impact on general outcome in metastatic breast cancer?

Heather L. McArthur, Clifford A. Hudis

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


According to the WHO World Cancer Report, 2003. breast cancer is a global public health burden with more than one million new cases diagnosed worldwide each year. Despite the diminished frequency of advanced-stage disease at initial diagnosis in some parts or the world, a significant proportion of women with early-stage disease eventually experience distant recurrences. Metastatic breast cancer is generally incurable and treatment is aimed of extending survival and improving quality-of-life. Efforts to optimize these paradigms are ongoing. In the last 30 years, significant innovations in drug delivery, scheduling and biologic therapies have resulted in significant improvements in disease-specific outcomet in the metastatic setting. One hopes that ongoing innovations, particularly in targeted therapy, will continue to translate into further improvements in this population.

Original languageEnglish (US)
Pages (from-to)411-418
Number of pages8
JournalFuture Oncology
Issue number4
StatePublished - Aug 2007
Externally publishedYes


  • Breast cancer
  • Chemotherapy
  • Metastatic

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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