@article{532c63ec94eb4874ab5a085cebce852e,
title = "Harmonized outcome measures for use in depression patient registries and clinical practice",
abstract = "Major depressive disorder is a common mental health condition that affects an estimated 16.2 million adults and 3.1 million adolescents in the United States. Yet, a lack of uniformity remains in measurements and monitoring for depression both in clinical practice and in research settings. This project aimed to develop a minimum set of standardized outcome measures relevant to both patients and clinicians that can be collected in depression registries and clinical practice. Twenty-nine depression registries and related data collection efforts were identified and invited to submit outcome measures. Additional measures were identified through literature searches and reviews of quality measures. A multistakeholder panel representing clinicians; payers; government agencies; industry; and medical specialty, health care quality, and patient advocacy organizations categorized the 27 identified measures using the Agency for Healthcare Research and Quality's supported Outcome Measures Framework. The panel identified 10 broadly relevant measures and harmonized definitions for these measures through in-person and virtual meetings. The harmonized measures represent a minimum set of outcomes that are relevant to clinicians and patients and appropriate for use in depression research and clinical practice. Routine and consistent collection of these measures in registries and other systems would support creation of a national research infrastructure to efficiently address new questions, improve patient management and outcomes, and facilitate care coordination.",
author = "Gliklich, {Richard E.} and Leavy, {Michelle B.} and Lisa Cosgrove and Simon, {Gregory E.} and Gaynes, {Bradley N.} and Peterson, {Lars E.} and Bryan Olin and Collette Cole and DePaulo, {J. Raymond} and Philip Wang and Crowe, {Chris M.} and Cristina Cusin and Mary Nix and Elise Berliner and Trivedi, {Madhukar H.}",
note = "Funding Information: Disclosures: Dr. Gliklich reports a contract with AHRQ during the conduct of the study and that he is an employee and stockholder of OM1 outside the submitted work. Ms. Leavy is an employee and stockholder of OM1, which received funding from AHRQ for this work. Dr. Simon reports grants from the National Institute of Mental Health during the conduct of the study. Dr. Gaynes reports grants from AHRQ, personal fees from Janssen Pharmaceuticals, and personal fees from LivaNova Cyberonics outside the submitted work. Dr. Olin reports employment with LivaNova outside the submitted work. Ms. Cole reports that the company she works for, MN Community Measurement, is a nonprofit collaborative organization that publicly reports health care quality and cost information. As part of its mission, the company also develops measures to meet gaps of identified measurement need. MN Community Measurement has developed a suite of depression process and outcome measures that were reviewed as part of this harmonization project. Dr. DePaulo reports that he is chairperson of the National Network of Depression Centers Board of Directors and receives reimbursement for official travel in an amount less than $5000 annually. He is and has been an unpaid consultant to Myriad Neuroscience (formerly Assurex Health) on behalf of the National Network of Depression Centers for meetings in 2017 and 2019. The National Network of Depression Centers is compensated for his effort. Dr. DePaulo owns stock in CVS Health. Dr. Trivedi reports editorial compensation from Oxford University Press, Engage Health Media, and Healthcare Global Village; grants from Janssen Research and Development, J&J, Cancer Prevention and Research Institute of Texas, Patient-Centered Outcomes Research Institute, National Institute on Drug Abuse, and National Institute of Mental Health; and consulting/advisory board activities for Allergan, Alkermes, ACADIA Pharmaceuticals, AcademyHealth, Oxford PharmaGenesis, Otsuka America Pharmaceutical, MSI Methylation Sciences, Navitor, Lund-beck Research USA, Medscape, Janssen Pharmaceuticals, Merck, and Takeda Pharmaceuticals outside the submitted work. Authors not named here have disclosed no conflicts of interest. Disclosures can also be viewed at www.acponline.org /authors/icmje/ConflictOfInterestForms.do?msNum=M19-3818. Funding Information: Financial Support: This project was funded under contract HHSA290201400004C from the Agency for Healthcare Research and Quality (AHRQ) of the U.S. Department of Health and Human Services. The authors of this article are responsible for its content. Statements in the article do not necessarily represent the official views of or imply endorsement by AHRQ or the Department of Health and Human Services. This work was supported by the Office of the Secretary Patient-Centered Outcomes Research Trust Fund under interagency agreement #16-566R-16. Publisher Copyright: {\textcopyright} 2020 American College of Physicians. All rights reserved.",
year = "2020",
month = jun,
day = "16",
doi = "10.7326/M19-3818",
language = "English (US)",
volume = "172",
pages = "803--809",
journal = "Annals of Internal Medicine",
issn = "0003-4819",
publisher = "American College of Physicians",
number = "12",
}