TY - JOUR
T1 - Granular cell atypical fibroxanthoma
T2 - Case report and review of the literature
AU - Wright, Natalie A.
AU - Thomas, Crystal G.
AU - Calame, Antoanella
AU - Cockerell, Clay J.
PY - 2010/3
Y1 - 2010/3
N2 - We present a case of granular cell atypical fibroxanthoma of the scalp. The neoplasm occurred as a tender nodule on the frontal scalp of an 82-year-old Caucasian man. Histology demonstrated a diffuse proliferation of atypical epithelioid cells with abundant granular cytoplasm. Many of the cells had large irregular nuclei and atypical mitotic figures were present. Immunohistochemical stains were positive for CD68 and procollagen 1 and negative for cytokeratin, HMB-45 and S-100 proteThe granular cell phenotype has been observed in other cutaneous neoplasms including granular cell tumors, dermatofibromas, dermatofibrosarcoma protuberans, fibrous papules, basal cell carcinomas, leiomyosarcomas, angiosarcomas and primitive polypoid granular cell tumors. We discuss the differential diagnosis and review the previously reported cases of this rare variant of atypical fibroxanthoma.
AB - We present a case of granular cell atypical fibroxanthoma of the scalp. The neoplasm occurred as a tender nodule on the frontal scalp of an 82-year-old Caucasian man. Histology demonstrated a diffuse proliferation of atypical epithelioid cells with abundant granular cytoplasm. Many of the cells had large irregular nuclei and atypical mitotic figures were present. Immunohistochemical stains were positive for CD68 and procollagen 1 and negative for cytokeratin, HMB-45 and S-100 proteThe granular cell phenotype has been observed in other cutaneous neoplasms including granular cell tumors, dermatofibromas, dermatofibrosarcoma protuberans, fibrous papules, basal cell carcinomas, leiomyosarcomas, angiosarcomas and primitive polypoid granular cell tumors. We discuss the differential diagnosis and review the previously reported cases of this rare variant of atypical fibroxanthoma.
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U2 - 10.1111/j.1600-0560.2009.01297.x
DO - 10.1111/j.1600-0560.2009.01297.x
M3 - Article
C2 - 19341433
AN - SCOPUS:75749107080
SN - 0303-6987
VL - 37
SP - 380
EP - 385
JO - Journal of Cutaneous Pathology
JF - Journal of Cutaneous Pathology
IS - 3
ER -