Graded positional information: Interpretation for both fate and guidance

Miriam Osterfield; Marc W. Kirschner; John G. Flanagan

doi:10.1016/S0092-8674(03)00359-3

Graded positional information: Interpretation for both fate and guidance

Miriam Osterfield, Marc W. Kirschner, John G. Flanagan

Research output: Contribution to journal › Review article › peer-review

45 Scopus citations

Abstract

Recent evidence indicates that gradients of the same extracellular molecules can act as both morphogens, specifying cell differentiation, and guidance cues, directing axon movement. We discuss how cells may use common mechanisms to convert graded information into discrete responses; and how extracellular signals provide coordinate systems that can be linked to highly diverse cellular outputs.

Original language	English (US)
Pages (from-to)	425-428
Number of pages	4
Journal	Cell
Volume	113
Issue number	4
DOIs	https://doi.org/10.1016/S0092-8674(03)00359-3
State	Published - May 16 2003
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/S0092-8674(03)00359-3

Cite this

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title = "Graded positional information: Interpretation for both fate and guidance",

abstract = "Recent evidence indicates that gradients of the same extracellular molecules can act as both morphogens, specifying cell differentiation, and guidance cues, directing axon movement. We discuss how cells may use common mechanisms to convert graded information into discrete responses; and how extracellular signals provide coordinate systems that can be linked to highly diverse cellular outputs.",

author = "Miriam Osterfield and Kirschner, {Marc W.} and Flanagan, {John G.}",

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T2 - Interpretation for both fate and guidance

AU - Osterfield, Miriam

AU - Kirschner, Marc W.

AU - Flanagan, John G.

PY - 2003/5/16

Y1 - 2003/5/16

N2 - Recent evidence indicates that gradients of the same extracellular molecules can act as both morphogens, specifying cell differentiation, and guidance cues, directing axon movement. We discuss how cells may use common mechanisms to convert graded information into discrete responses; and how extracellular signals provide coordinate systems that can be linked to highly diverse cellular outputs.

AB - Recent evidence indicates that gradients of the same extracellular molecules can act as both morphogens, specifying cell differentiation, and guidance cues, directing axon movement. We discuss how cells may use common mechanisms to convert graded information into discrete responses; and how extracellular signals provide coordinate systems that can be linked to highly diverse cellular outputs.

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U2 - 10.1016/S0092-8674(03)00359-3

DO - 10.1016/S0092-8674(03)00359-3

M3 - Review article

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AN - SCOPUS:0038064282

SN - 0092-8674

VL - 113

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JO - Cell

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Graded positional information: Interpretation for both fate and guidance

Abstract

ASJC Scopus subject areas

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