Graded positional information: Interpretation for both fate and guidance

Miriam Osterfield, Marc W. Kirschner, John G. Flanagan

Research output: Contribution to journalReview articlepeer-review

45 Scopus citations


Recent evidence indicates that gradients of the same extracellular molecules can act as both morphogens, specifying cell differentiation, and guidance cues, directing axon movement. We discuss how cells may use common mechanisms to convert graded information into discrete responses; and how extracellular signals provide coordinate systems that can be linked to highly diverse cellular outputs.

Original languageEnglish (US)
Pages (from-to)425-428
Number of pages4
Issue number4
StatePublished - May 16 2003
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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