Gq-Gi-PLCβ in cells: More than the sum of its reconstituted parts

Thomas M. Wilkie, Michael A. Hale, Sarthak Reddy

Research output: Contribution to journalComment/debatepeer-review


The recent paper by Pfeil et al., “Heterotrimeric G Protein Subunit Gαq Is a Master Switch for Gβγ-Mediated Calcium Mobilization by Gi-Coupled GPCRs”, opens another path from biochemical in vitro reconstitution to understanding the complex regulation of calcium signaling inside the cell.

Original languageEnglish (US)
Article number102340
JournalCell Calcium
StatePublished - Mar 2021


  • Calcium signaling
  • Gi signaling
  • Gq signaling
  • RGS proteins

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology


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