Gonococcal lipopolysaccharide: A toxin for human fallopian tube mucosa

C. R. Gregg, M. A. Melly, Z. A. McGee

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Gonococci damaged the mucosa of human fallopian tubes in organ culture (FTOC), producing characteristic pathologic features. Filter-sterilized supernatant fluid from donor gonococcal-infected FTOC damaged recipient FTOC in a similar fashion. Gonococcal lipopolysaccharide (LPS) was detected in these toxic donor fluids in concentrations of 1.2 to 8.3 μg/ml. Purified gonococcal LPS in concentrations as low as 0.015 μg/ml produced damage equivalent to that caused by toxic donor fluid and was neutralized by polymyxin B. Such LPS-mediated damage to ciliated cells, if it occurs in gonococcal salpingitis, may impair mucociliary flow and predispose to ectopic pregnancy and recurrent ascending infection.

Original languageEnglish (US)
Pages (from-to)981-984
Number of pages4
JournalAmerican journal of obstetrics and gynecology
Issue number7 PART 2
StatePublished - Dec 1 1980

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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