Gonococcal lipopolysaccharide: A toxin for human fallopian tube mucosa

C. R. Gregg; M. A. Melly; Z. A. McGee

doi:10.1016/0002-9378(80)91092-3

Gonococcal lipopolysaccharide: A toxin for human fallopian tube mucosa

C. R. Gregg, M. A. Melly, Z. A. McGee

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Gonococci damaged the mucosa of human fallopian tubes in organ culture (FTOC), producing characteristic pathologic features. Filter-sterilized supernatant fluid from donor gonococcal-infected FTOC damaged recipient FTOC in a similar fashion. Gonococcal lipopolysaccharide (LPS) was detected in these toxic donor fluids in concentrations of 1.2 to 8.3 μg/ml. Purified gonococcal LPS in concentrations as low as 0.015 μg/ml produced damage equivalent to that caused by toxic donor fluid and was neutralized by polymyxin B. Such LPS-mediated damage to ciliated cells, if it occurs in gonococcal salpingitis, may impair mucociliary flow and predispose to ectopic pregnancy and recurrent ascending infection.

Original language	English (US)
Pages (from-to)	981-984
Number of pages	4
Journal	American journal of obstetrics and gynecology
Volume	138
Issue number	7 PART 2
DOIs	https://doi.org/10.1016/0002-9378(80)91092-3
State	Published - Dec 1 1980

ASJC Scopus subject areas

Obstetrics and Gynecology

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title = "Gonococcal lipopolysaccharide: A toxin for human fallopian tube mucosa",

abstract = "Gonococci damaged the mucosa of human fallopian tubes in organ culture (FTOC), producing characteristic pathologic features. Filter-sterilized supernatant fluid from donor gonococcal-infected FTOC damaged recipient FTOC in a similar fashion. Gonococcal lipopolysaccharide (LPS) was detected in these toxic donor fluids in concentrations of 1.2 to 8.3 μg/ml. Purified gonococcal LPS in concentrations as low as 0.015 μg/ml produced damage equivalent to that caused by toxic donor fluid and was neutralized by polymyxin B. Such LPS-mediated damage to ciliated cells, if it occurs in gonococcal salpingitis, may impair mucociliary flow and predispose to ectopic pregnancy and recurrent ascending infection.",

author = "Gregg, {C. R.} and Melly, {M. A.} and McGee, {Z. A.}",

note = "Funding Information: These studies were supported by United States Public Health Service Research Grant AI-13488 from the National Institute of Allergy and Infectio& Disea.ses. Dr. Gregg participatPd in these studies while a recipient of Natimull Research Sewice Award AI-05533 from the National Institute of Allergy and Infectious Diseases.",

year = "1980",

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doi = "10.1016/0002-9378(80)91092-3",

language = "English (US)",

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T1 - Gonococcal lipopolysaccharide

T2 - A toxin for human fallopian tube mucosa

AU - Gregg, C. R.

AU - Melly, M. A.

AU - McGee, Z. A.

N1 - Funding Information: These studies were supported by United States Public Health Service Research Grant AI-13488 from the National Institute of Allergy and Infectio& Disea.ses. Dr. Gregg participatPd in these studies while a recipient of Natimull Research Sewice Award AI-05533 from the National Institute of Allergy and Infectious Diseases.

PY - 1980/12/1

Y1 - 1980/12/1

N2 - Gonococci damaged the mucosa of human fallopian tubes in organ culture (FTOC), producing characteristic pathologic features. Filter-sterilized supernatant fluid from donor gonococcal-infected FTOC damaged recipient FTOC in a similar fashion. Gonococcal lipopolysaccharide (LPS) was detected in these toxic donor fluids in concentrations of 1.2 to 8.3 μg/ml. Purified gonococcal LPS in concentrations as low as 0.015 μg/ml produced damage equivalent to that caused by toxic donor fluid and was neutralized by polymyxin B. Such LPS-mediated damage to ciliated cells, if it occurs in gonococcal salpingitis, may impair mucociliary flow and predispose to ectopic pregnancy and recurrent ascending infection.

AB - Gonococci damaged the mucosa of human fallopian tubes in organ culture (FTOC), producing characteristic pathologic features. Filter-sterilized supernatant fluid from donor gonococcal-infected FTOC damaged recipient FTOC in a similar fashion. Gonococcal lipopolysaccharide (LPS) was detected in these toxic donor fluids in concentrations of 1.2 to 8.3 μg/ml. Purified gonococcal LPS in concentrations as low as 0.015 μg/ml produced damage equivalent to that caused by toxic donor fluid and was neutralized by polymyxin B. Such LPS-mediated damage to ciliated cells, if it occurs in gonococcal salpingitis, may impair mucociliary flow and predispose to ectopic pregnancy and recurrent ascending infection.

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IS - 7 PART 2

ER -

Gonococcal lipopolysaccharide: A toxin for human fallopian tube mucosa

Abstract

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