Golgi biogenesis

Yanzhuang Wang, Joachim Seemann

Research output: Contribution to journalArticlepeer-review

58 Scopus citations


The Golgi is an essential membrane-bound organelle in the secretary pathway of eukaryotic cells. In mammalian cells, the Golgi stacks are integrated into a continuous perinuclear ribbon, which poses a challenge for the daughter cells to inherit this membrane organelle during cell division. To facilitate proper partitioning, the mammalian Golgi ribbon is disassembled into vesicles in early mitosis. Following segregation into the daughter cells, a functional Golgi is reformed. Here we summarize our current understanding of the molecular mechanisms that control the mitotic Golgi disassembly and postmitotic reassembly cycle in mammalian cells.

Original languageEnglish (US)
Pages (from-to)1-12
Number of pages12
JournalCold Spring Harbor Perspectives in Biology
Issue number10
StatePublished - Oct 2011

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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