@inproceedings{49302da24d76413cac37d90b77c1e0c9,
title = "Gold nanoprobes for multi-modality tumor imaging",
abstract = "Gold nanoparticles have been shown to possess x-ray attenuation higher than that of clinically used iodine based contrast agents. Additionally, gold nanoparticles have also been used in enhancing the Raman signal through a phenomenon called Surface Enhanced Raman Scattering (SERS). The development of Gold nanoparticle based probes (nanotags) for combined SERS and x-ray computed tomography (CT) are reported. These nanotags comprise quasi-spherical gold nanoparticles encoded using a Raman active molecule and encapsulated by a monolayer of polyethylene glycol with carboxylate functional groups for bioconjugation. The nanotags, made from ∼65 nm gold nanoparticles, display large SERS cross-section and x-ray absorption which are used for dual modality imaging of tumor cells in of an orthotropic prostate cancer tumor animal model.",
keywords = "Computed tomography, Gold nanoparticles, Orthotropic, Surface enhanced Raman scattering, Tumor",
author = "James Nyagilo and Ming Xiao and Xiankai Sun and Dav{\'e}, {Digant P.}",
year = "2010",
doi = "10.1117/12.842917",
language = "English (US)",
isbn = "9780819479723",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications II",
note = "Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications II ; Conference date: 25-01-2010 Through 27-01-2010",
}