Abstract
Allergic asthma is characterized by a temporally and quantitatively inappropriate immunologic response. One of the hallmarks of this response is the accumulation of eosinophils in the airway and lung parenchyma, which results in broncho-constriction, lung damage and, ultimately, fibrosis. Granulocyte-macrophage colony-stimulating factor (GM-CSF) plays a pivotal role in this process by modulating eosinophil function and survival. In this review, we discuss the effects and molecular regulation of GM-CSF secretion by eosinophils. Recent data demonstrate that activated eosinophils release small amounts of anti-apoptotic GM-CSF by stabilizing its coding mRNA.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 121-130 |
| Number of pages | 10 |
| Journal | Archivum Immunologiae et Therapiae Experimentalis |
| Volume | 50 |
| Issue number | 2 |
| State | Published - 2002 |
Keywords
- Asthma
- Eosinophils
- GM-CSF
- Survival
- mRNA
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology