Gluttony, sloth and the metabolic syndrome: A roadmap to lipotoxicity

Roger H Unger, Philipp E Scherer

Research output: Contribution to journalReview articlepeer-review

308 Scopus citations


Once considered divine retribution for sins, comorbidities of obesity (metabolic syndrome) are today attributed to obesity-induced metabolic defects. Here, we propose that obesity and hyperleptinemia protect lipid-intolerant nonadipose organs against lipotoxic lipid spillover during sustained caloric surplus. Metabolic syndrome is ascribed to lipotoxicity caused by age-related resistance to antilipotoxic protection by leptin.

Original languageEnglish (US)
Pages (from-to)345-352
Number of pages8
JournalTrends in Endocrinology and Metabolism
Issue number6
StatePublished - Jun 2010

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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