Glutathione and glutathione linked enzymes in human small cell lung cancer cell lines

Rashmi Sharma; Sharad S. Singhal; Sanjay K. Srivastava; Krishna K. Bajpai; Eugene P. Frenkel; Sanjay Awasthi

doi:10.1016/0304-3835(93)90195-F

Glutathione and glutathione linked enzymes in human small cell lung cancer cell lines

Rashmi Sharma, Sharad S. Singhal, Sanjay K. Srivastava, Krishna K. Bajpai, Eugene P. Frenkel, Sanjay Awasthi

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32 Scopus citations

Abstract

Glutathione levels and several glutathione-linked enzyme activities have been variably correlated with cisplatin chemosensitivity in cultured neoplastic cells. In order to determine the relative contribution of the glutathione-linked enzymes towards mediating inherent cisplatin resistance in cancer cells, we have measured the chemosensitivity to cisplatin, glutathione levels and activities of glutathione S-transferase, glutathione peroxidase, glutathione reductase and glucose-6-phosphate dehydrogenase in 8 cultured human small cell lung cance (SCLC) cell lines with widely differing cisplatin sensitivities. Of these parameters, only glutathione S-transferase activity correlated with degree of cisplatin resistance in a linear fashion.

Original language	English (US)
Pages (from-to)	111-119
Number of pages	9
Journal	Cancer Letters
Volume	75
Issue number	2
DOIs	https://doi.org/10.1016/0304-3835(93)90195-F
State	Published - Dec 10 1993

Keywords

Cisplatin
Drug resistance
Glutathione
Glutathione S-transferase
Small cell lung cancer

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/0304-3835(93)90195-F

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title = "Glutathione and glutathione linked enzymes in human small cell lung cancer cell lines",

abstract = "Glutathione levels and several glutathione-linked enzyme activities have been variably correlated with cisplatin chemosensitivity in cultured neoplastic cells. In order to determine the relative contribution of the glutathione-linked enzymes towards mediating inherent cisplatin resistance in cancer cells, we have measured the chemosensitivity to cisplatin, glutathione levels and activities of glutathione S-transferase, glutathione peroxidase, glutathione reductase and glucose-6-phosphate dehydrogenase in 8 cultured human small cell lung cance (SCLC) cell lines with widely differing cisplatin sensitivities. Of these parameters, only glutathione S-transferase activity correlated with degree of cisplatin resistance in a linear fashion.",

keywords = "Cisplatin, Drug resistance, Glutathione, Glutathione S-transferase, Small cell lung cancer",

author = "Rashmi Sharma and Singhal, {Sharad S.} and Srivastava, {Sanjay K.} and Bajpai, {Krishna K.} and Frenkel, {Eugene P.} and Sanjay Awasthi",

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T1 - Glutathione and glutathione linked enzymes in human small cell lung cancer cell lines

AU - Sharma, Rashmi

AU - Singhal, Sharad S.

AU - Srivastava, Sanjay K.

AU - Bajpai, Krishna K.

AU - Frenkel, Eugene P.

AU - Awasthi, Sanjay

PY - 1993/12/10

Y1 - 1993/12/10

N2 - Glutathione levels and several glutathione-linked enzyme activities have been variably correlated with cisplatin chemosensitivity in cultured neoplastic cells. In order to determine the relative contribution of the glutathione-linked enzymes towards mediating inherent cisplatin resistance in cancer cells, we have measured the chemosensitivity to cisplatin, glutathione levels and activities of glutathione S-transferase, glutathione peroxidase, glutathione reductase and glucose-6-phosphate dehydrogenase in 8 cultured human small cell lung cance (SCLC) cell lines with widely differing cisplatin sensitivities. Of these parameters, only glutathione S-transferase activity correlated with degree of cisplatin resistance in a linear fashion.

AB - Glutathione levels and several glutathione-linked enzyme activities have been variably correlated with cisplatin chemosensitivity in cultured neoplastic cells. In order to determine the relative contribution of the glutathione-linked enzymes towards mediating inherent cisplatin resistance in cancer cells, we have measured the chemosensitivity to cisplatin, glutathione levels and activities of glutathione S-transferase, glutathione peroxidase, glutathione reductase and glucose-6-phosphate dehydrogenase in 8 cultured human small cell lung cance (SCLC) cell lines with widely differing cisplatin sensitivities. Of these parameters, only glutathione S-transferase activity correlated with degree of cisplatin resistance in a linear fashion.

KW - Cisplatin

KW - Drug resistance

KW - Glutathione

KW - Glutathione S-transferase

KW - Small cell lung cancer

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Glutathione and glutathione linked enzymes in human small cell lung cancer cell lines

Abstract

Keywords

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