Global brain hypoperfusion and oxygenation in amnestic mild cognitive impairment

Jie Liu, Yong Sheng Zhu, Muhammad Ayaz Khan, Estee Brunk, Kristin Martin-Cook, Myron F. Weiner, C. Munro Cullum, Hanzhang Lu, Benjamin D. Levine, Ramon Diaz-Arrastia, Rong Zhang

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


Background To determine if global brain hypoperfusion and oxygen hypometabolism occur in patients with amnestic mild cognitive impairment (aMCI). Methods Thirty-two aMCI and 21 normal subjects participated. Total cerebral blood flow (TCBF), cerebral metabolic rate of oxygen (CMRO2), and brain tissue volume were measured using color-coded duplex ultrasonography (CDUS), near-infrared spectroscopy (NIRS), and MRI. TCBF was normalized by total brain tissue volume (TBV) for group comparisons (nTCBF). Cerebrovascular resistance (CVR) was calculated as mean arterial pressure divided by TCBF. Results Reductions in nTCBF by 9%, CMRO2 by 11%, and an increase in CVR by 13% were observed in aMCI relative to normal subjects. No group differences in TBV were observed. nTCBF was correlated with CMRO2 in normal controls, but not in aMCI. Conclusions Global brain hypoperfusion, oxygen hypometabolism, and neurovascular decoupling observed in aMCI suggest that changes in cerebral hemodynamics occur early at a prodromal stage of Alzheimer's disease, which can be assessed using low-cost and bedside-available CDUS and NIRS technology.

Original languageEnglish (US)
Pages (from-to)162-170
Number of pages9
JournalAlzheimer's and Dementia
Issue number2
StatePublished - Mar 2014


  • Cerebral blood flow
  • Cerebral metabolic rate of oxygen
  • MRI
  • Mild cognitive impairment
  • Near-infrared spectroscopy
  • Ultrasonography

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience


Dive into the research topics of 'Global brain hypoperfusion and oxygenation in amnestic mild cognitive impairment'. Together they form a unique fingerprint.

Cite this