Glioblastoma cancer stem cells - From concept to clinical application

Barbara E. Stopschinski; Christoph P. Beier; Dagmar Beier

doi:10.1016/j.canlet.2012.05.033

Glioblastoma cancer stem cells - From concept to clinical application

Barbara E. Stopschinski, Christoph P. Beier, Dagmar Beier

Research output: Contribution to journal › Review article › peer-review

59 Scopus citations

Abstract

Ten years after the first description of cancer stem cells (CSCs) in glioblastoma (GBM), the initial concept of CSC has been challenged and our understanding of cellular heterogeneity within malignant brain tumors became more complex. The increasing knowledge on CSC also influences preclinical research and clinical practice. This review therefore describes current concepts and controversies on CSC in GBM and summarizes the recent progress how the CSC hypothesis is about to translate into preclinical and clinical application.

Original language	English (US)
Pages (from-to)	32-40
Number of pages	9
Journal	Cancer Letters
Volume	338
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2012.05.033
State	Published - Sep 10 2013
Externally published	Yes

Keywords

Cancer stem cells
CD133
Chemoresistance
Glioblastoma
Radioresistance

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.canlet.2012.05.033

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title = "Glioblastoma cancer stem cells - From concept to clinical application",

abstract = "Ten years after the first description of cancer stem cells (CSCs) in glioblastoma (GBM), the initial concept of CSC has been challenged and our understanding of cellular heterogeneity within malignant brain tumors became more complex. The increasing knowledge on CSC also influences preclinical research and clinical practice. This review therefore describes current concepts and controversies on CSC in GBM and summarizes the recent progress how the CSC hypothesis is about to translate into preclinical and clinical application.",

keywords = "Cancer stem cells, CD133, Chemoresistance, Glioblastoma, Radioresistance",

author = "Stopschinski, {Barbara E.} and Beier, {Christoph P.} and Dagmar Beier",

note = "Funding Information: This work was supported by a career award to young female scientists of the RWTH Aachen, Medical School to DB. Parts of the project were funded by the NGFNplus Brain Tumor Network to CPB (Subproject 7B 01GS1105) and the in-house research support of the RWTH Aachen, Medical School (START-Program) to DB.",

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T1 - Glioblastoma cancer stem cells - From concept to clinical application

AU - Stopschinski, Barbara E.

AU - Beier, Christoph P.

AU - Beier, Dagmar

N1 - Funding Information: This work was supported by a career award to young female scientists of the RWTH Aachen, Medical School to DB. Parts of the project were funded by the NGFNplus Brain Tumor Network to CPB (Subproject 7B 01GS1105) and the in-house research support of the RWTH Aachen, Medical School (START-Program) to DB.

PY - 2013/9/10

Y1 - 2013/9/10

N2 - Ten years after the first description of cancer stem cells (CSCs) in glioblastoma (GBM), the initial concept of CSC has been challenged and our understanding of cellular heterogeneity within malignant brain tumors became more complex. The increasing knowledge on CSC also influences preclinical research and clinical practice. This review therefore describes current concepts and controversies on CSC in GBM and summarizes the recent progress how the CSC hypothesis is about to translate into preclinical and clinical application.

AB - Ten years after the first description of cancer stem cells (CSCs) in glioblastoma (GBM), the initial concept of CSC has been challenged and our understanding of cellular heterogeneity within malignant brain tumors became more complex. The increasing knowledge on CSC also influences preclinical research and clinical practice. This review therefore describes current concepts and controversies on CSC in GBM and summarizes the recent progress how the CSC hypothesis is about to translate into preclinical and clinical application.

KW - Cancer stem cells

KW - CD133

KW - Chemoresistance

KW - Glioblastoma

KW - Radioresistance

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Glioblastoma cancer stem cells - From concept to clinical application

Abstract

Keywords

ASJC Scopus subject areas

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