Glioblastoma cancer stem cells - From concept to clinical application

Barbara E. Stopschinski, Christoph P. Beier, Dagmar Beier

Research output: Contribution to journalReview articlepeer-review

60 Scopus citations

Abstract

Ten years after the first description of cancer stem cells (CSCs) in glioblastoma (GBM), the initial concept of CSC has been challenged and our understanding of cellular heterogeneity within malignant brain tumors became more complex. The increasing knowledge on CSC also influences preclinical research and clinical practice. This review therefore describes current concepts and controversies on CSC in GBM and summarizes the recent progress how the CSC hypothesis is about to translate into preclinical and clinical application.

Original languageEnglish (US)
Pages (from-to)32-40
Number of pages9
JournalCancer Letters
Volume338
Issue number1
DOIs
StatePublished - Sep 10 2013
Externally publishedYes

Keywords

  • Cancer stem cells
  • CD133
  • Chemoresistance
  • Glioblastoma
  • Radioresistance

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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